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Post-Infectious Guillain–Barré Syndrome Related to SARS-CoV-2 Infection: A Systematic Review

Background. Guillain-Barré syndrome (GBS) is the most common cause of flaccid paralysis, with about 100,000 people developing the disorder every year worldwide. Recently, the incidence of GBS has increased during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemics. We reviewed...

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Autores principales: Sansone, Pasquale, Giaccari, Luca Gregorio, Aurilio, Caterina, Coppolino, Francesco, Esposito, Valentina, Fiore, Marco, Paladini, Antonella, Passavanti, Maria Beatrice, Pota, Vincenzo, Pace, Maria Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926636/
https://www.ncbi.nlm.nih.gov/pubmed/33670000
http://dx.doi.org/10.3390/life11020167
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author Sansone, Pasquale
Giaccari, Luca Gregorio
Aurilio, Caterina
Coppolino, Francesco
Esposito, Valentina
Fiore, Marco
Paladini, Antonella
Passavanti, Maria Beatrice
Pota, Vincenzo
Pace, Maria Caterina
author_facet Sansone, Pasquale
Giaccari, Luca Gregorio
Aurilio, Caterina
Coppolino, Francesco
Esposito, Valentina
Fiore, Marco
Paladini, Antonella
Passavanti, Maria Beatrice
Pota, Vincenzo
Pace, Maria Caterina
author_sort Sansone, Pasquale
collection PubMed
description Background. Guillain-Barré syndrome (GBS) is the most common cause of flaccid paralysis, with about 100,000 people developing the disorder every year worldwide. Recently, the incidence of GBS has increased during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemics. We reviewed the literature to give a comprehensive overview of the demographic characteristics, clinical features, diagnostic investigations, and outcome of SARS-CoV-2-related GBS patients. Methods. Embase, MEDLINE, Google Scholar, and Cochrane Central Trials Register were systematically searched on 24 September 2020 for studies reporting on GBS secondary to COVID-19. Results. We identified 63 articles; we included 32 studies in our review. A total of 41 GBS cases with a confirmed or probable COVID-19 infection were reported: 26 of them were single case reports and 6 case series. Published studies on SARS-CoV-2-related GBS typically report a classic sensorimotor type of GBS often with a demyelinating electrophysiological subtype. Miller Fisher syndrome was reported in a quarter of the cases. In 78.1% of the cases, the response to immunomodulating therapy is favourable. The disease course is frequently severe and about one-third of the patients with SARS-CoV-2-associated GBS requires mechanical ventilation and Intensive Care Unit (ICU) admission. Rarely the outcome is poor or even fatal (10.8% of the cases). Conclusion. Clinical presentation, course, response to treatment, and outcome are similar in SARS-CoV-2-associated GBS and GBS due to other triggers.
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spelling pubmed-79266362021-03-04 Post-Infectious Guillain–Barré Syndrome Related to SARS-CoV-2 Infection: A Systematic Review Sansone, Pasquale Giaccari, Luca Gregorio Aurilio, Caterina Coppolino, Francesco Esposito, Valentina Fiore, Marco Paladini, Antonella Passavanti, Maria Beatrice Pota, Vincenzo Pace, Maria Caterina Life (Basel) Review Background. Guillain-Barré syndrome (GBS) is the most common cause of flaccid paralysis, with about 100,000 people developing the disorder every year worldwide. Recently, the incidence of GBS has increased during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemics. We reviewed the literature to give a comprehensive overview of the demographic characteristics, clinical features, diagnostic investigations, and outcome of SARS-CoV-2-related GBS patients. Methods. Embase, MEDLINE, Google Scholar, and Cochrane Central Trials Register were systematically searched on 24 September 2020 for studies reporting on GBS secondary to COVID-19. Results. We identified 63 articles; we included 32 studies in our review. A total of 41 GBS cases with a confirmed or probable COVID-19 infection were reported: 26 of them were single case reports and 6 case series. Published studies on SARS-CoV-2-related GBS typically report a classic sensorimotor type of GBS often with a demyelinating electrophysiological subtype. Miller Fisher syndrome was reported in a quarter of the cases. In 78.1% of the cases, the response to immunomodulating therapy is favourable. The disease course is frequently severe and about one-third of the patients with SARS-CoV-2-associated GBS requires mechanical ventilation and Intensive Care Unit (ICU) admission. Rarely the outcome is poor or even fatal (10.8% of the cases). Conclusion. Clinical presentation, course, response to treatment, and outcome are similar in SARS-CoV-2-associated GBS and GBS due to other triggers. MDPI 2021-02-21 /pmc/articles/PMC7926636/ /pubmed/33670000 http://dx.doi.org/10.3390/life11020167 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sansone, Pasquale
Giaccari, Luca Gregorio
Aurilio, Caterina
Coppolino, Francesco
Esposito, Valentina
Fiore, Marco
Paladini, Antonella
Passavanti, Maria Beatrice
Pota, Vincenzo
Pace, Maria Caterina
Post-Infectious Guillain–Barré Syndrome Related to SARS-CoV-2 Infection: A Systematic Review
title Post-Infectious Guillain–Barré Syndrome Related to SARS-CoV-2 Infection: A Systematic Review
title_full Post-Infectious Guillain–Barré Syndrome Related to SARS-CoV-2 Infection: A Systematic Review
title_fullStr Post-Infectious Guillain–Barré Syndrome Related to SARS-CoV-2 Infection: A Systematic Review
title_full_unstemmed Post-Infectious Guillain–Barré Syndrome Related to SARS-CoV-2 Infection: A Systematic Review
title_short Post-Infectious Guillain–Barré Syndrome Related to SARS-CoV-2 Infection: A Systematic Review
title_sort post-infectious guillain–barré syndrome related to sars-cov-2 infection: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926636/
https://www.ncbi.nlm.nih.gov/pubmed/33670000
http://dx.doi.org/10.3390/life11020167
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