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Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?

Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Ce...

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Autores principales: Sena-dos-Santos, Camille, Braga-da-Silva, Cíntia, Marques, Diego, Azevedo dos Santos Pinheiro, Jhully, Ribeiro-dos-Santos, Ândrea, Cavalcante, Giovanna C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926694/
https://www.ncbi.nlm.nih.gov/pubmed/33672278
http://dx.doi.org/10.3390/cells10020479
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author Sena-dos-Santos, Camille
Braga-da-Silva, Cíntia
Marques, Diego
Azevedo dos Santos Pinheiro, Jhully
Ribeiro-dos-Santos, Ândrea
Cavalcante, Giovanna C.
author_facet Sena-dos-Santos, Camille
Braga-da-Silva, Cíntia
Marques, Diego
Azevedo dos Santos Pinheiro, Jhully
Ribeiro-dos-Santos, Ândrea
Cavalcante, Giovanna C.
author_sort Sena-dos-Santos, Camille
collection PubMed
description Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Cell death is implicated in malaria immune responses by eliminating infected cells, but it can also provoke an intense inflammatory response and lead to severe malaria outcomes. The study of the pathophysiological role of cell death in malaria in mammalians is key to understanding the parasite–host interactions and design prophylactic and therapeutic strategies for malaria. In this work, we review malaria-triggered cell death pathways (apoptosis, autophagy, necrosis, pyroptosis, NETosis, and ferroptosis) and we discuss their potential role in the development of new approaches for human malaria therapies.
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spelling pubmed-79266942021-03-04 Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? Sena-dos-Santos, Camille Braga-da-Silva, Cíntia Marques, Diego Azevedo dos Santos Pinheiro, Jhully Ribeiro-dos-Santos, Ândrea Cavalcante, Giovanna C. Cells Review Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Cell death is implicated in malaria immune responses by eliminating infected cells, but it can also provoke an intense inflammatory response and lead to severe malaria outcomes. The study of the pathophysiological role of cell death in malaria in mammalians is key to understanding the parasite–host interactions and design prophylactic and therapeutic strategies for malaria. In this work, we review malaria-triggered cell death pathways (apoptosis, autophagy, necrosis, pyroptosis, NETosis, and ferroptosis) and we discuss their potential role in the development of new approaches for human malaria therapies. MDPI 2021-02-23 /pmc/articles/PMC7926694/ /pubmed/33672278 http://dx.doi.org/10.3390/cells10020479 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sena-dos-Santos, Camille
Braga-da-Silva, Cíntia
Marques, Diego
Azevedo dos Santos Pinheiro, Jhully
Ribeiro-dos-Santos, Ândrea
Cavalcante, Giovanna C.
Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
title Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
title_full Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
title_fullStr Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
title_full_unstemmed Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
title_short Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
title_sort unraveling cell death pathways during malaria infection: what do we know so far?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926694/
https://www.ncbi.nlm.nih.gov/pubmed/33672278
http://dx.doi.org/10.3390/cells10020479
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