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Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?
Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Ce...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926694/ https://www.ncbi.nlm.nih.gov/pubmed/33672278 http://dx.doi.org/10.3390/cells10020479 |
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author | Sena-dos-Santos, Camille Braga-da-Silva, Cíntia Marques, Diego Azevedo dos Santos Pinheiro, Jhully Ribeiro-dos-Santos, Ândrea Cavalcante, Giovanna C. |
author_facet | Sena-dos-Santos, Camille Braga-da-Silva, Cíntia Marques, Diego Azevedo dos Santos Pinheiro, Jhully Ribeiro-dos-Santos, Ândrea Cavalcante, Giovanna C. |
author_sort | Sena-dos-Santos, Camille |
collection | PubMed |
description | Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Cell death is implicated in malaria immune responses by eliminating infected cells, but it can also provoke an intense inflammatory response and lead to severe malaria outcomes. The study of the pathophysiological role of cell death in malaria in mammalians is key to understanding the parasite–host interactions and design prophylactic and therapeutic strategies for malaria. In this work, we review malaria-triggered cell death pathways (apoptosis, autophagy, necrosis, pyroptosis, NETosis, and ferroptosis) and we discuss their potential role in the development of new approaches for human malaria therapies. |
format | Online Article Text |
id | pubmed-7926694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79266942021-03-04 Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? Sena-dos-Santos, Camille Braga-da-Silva, Cíntia Marques, Diego Azevedo dos Santos Pinheiro, Jhully Ribeiro-dos-Santos, Ândrea Cavalcante, Giovanna C. Cells Review Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Cell death is implicated in malaria immune responses by eliminating infected cells, but it can also provoke an intense inflammatory response and lead to severe malaria outcomes. The study of the pathophysiological role of cell death in malaria in mammalians is key to understanding the parasite–host interactions and design prophylactic and therapeutic strategies for malaria. In this work, we review malaria-triggered cell death pathways (apoptosis, autophagy, necrosis, pyroptosis, NETosis, and ferroptosis) and we discuss their potential role in the development of new approaches for human malaria therapies. MDPI 2021-02-23 /pmc/articles/PMC7926694/ /pubmed/33672278 http://dx.doi.org/10.3390/cells10020479 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sena-dos-Santos, Camille Braga-da-Silva, Cíntia Marques, Diego Azevedo dos Santos Pinheiro, Jhully Ribeiro-dos-Santos, Ândrea Cavalcante, Giovanna C. Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? |
title | Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? |
title_full | Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? |
title_fullStr | Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? |
title_full_unstemmed | Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? |
title_short | Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? |
title_sort | unraveling cell death pathways during malaria infection: what do we know so far? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926694/ https://www.ncbi.nlm.nih.gov/pubmed/33672278 http://dx.doi.org/10.3390/cells10020479 |
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