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Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer
Obesity is rapidly dispersing all around the world and is closely associated with a high risk of metabolic diseases such as insulin resistance, dyslipidemia, and nonalcoholic fatty liver disease (NAFLD), leading to carcinogenesis, especially hepatocellular carcinoma (HCC). It results from an imbalan...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926723/ https://www.ncbi.nlm.nih.gov/pubmed/33671547 http://dx.doi.org/10.3390/ijms22042163 |
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author | Rajesh, Yetirajam Sarkar, Devanand |
author_facet | Rajesh, Yetirajam Sarkar, Devanand |
author_sort | Rajesh, Yetirajam |
collection | PubMed |
description | Obesity is rapidly dispersing all around the world and is closely associated with a high risk of metabolic diseases such as insulin resistance, dyslipidemia, and nonalcoholic fatty liver disease (NAFLD), leading to carcinogenesis, especially hepatocellular carcinoma (HCC). It results from an imbalance between food intake and energy expenditure, leading to an excessive accumulation of adipose tissue (AT). Adipocytes play a substantial role in the tumor microenvironment through the secretion of several adipokines, affecting cancer progression, metastasis, and chemoresistance via diverse signaling pathways. AT is considered an endocrine organ owing to its ability to secrete adipokines, such as leptin, adiponectin, resistin, and a plethora of inflammatory cytokines, which modulate insulin sensitivity and trigger chronic low-grade inflammation in different organs. Even though the precise mechanisms are still unfolding, it is now established that the dysregulated secretion of adipokines by AT contributes to the development of obesity-related metabolic disorders. This review focuses on several obesity-associated adipokines and their impact on obesity-related metabolic diseases, subsequent metabolic complications, and progression to HCC, as well as their role as potential therapeutic targets. The field is rapidly developing, and further research is still required to fully understand the underlying mechanisms for the metabolic actions of adipokines and their role in obesity-associated HCC. |
format | Online Article Text |
id | pubmed-7926723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79267232021-03-04 Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer Rajesh, Yetirajam Sarkar, Devanand Int J Mol Sci Review Obesity is rapidly dispersing all around the world and is closely associated with a high risk of metabolic diseases such as insulin resistance, dyslipidemia, and nonalcoholic fatty liver disease (NAFLD), leading to carcinogenesis, especially hepatocellular carcinoma (HCC). It results from an imbalance between food intake and energy expenditure, leading to an excessive accumulation of adipose tissue (AT). Adipocytes play a substantial role in the tumor microenvironment through the secretion of several adipokines, affecting cancer progression, metastasis, and chemoresistance via diverse signaling pathways. AT is considered an endocrine organ owing to its ability to secrete adipokines, such as leptin, adiponectin, resistin, and a plethora of inflammatory cytokines, which modulate insulin sensitivity and trigger chronic low-grade inflammation in different organs. Even though the precise mechanisms are still unfolding, it is now established that the dysregulated secretion of adipokines by AT contributes to the development of obesity-related metabolic disorders. This review focuses on several obesity-associated adipokines and their impact on obesity-related metabolic diseases, subsequent metabolic complications, and progression to HCC, as well as their role as potential therapeutic targets. The field is rapidly developing, and further research is still required to fully understand the underlying mechanisms for the metabolic actions of adipokines and their role in obesity-associated HCC. MDPI 2021-02-22 /pmc/articles/PMC7926723/ /pubmed/33671547 http://dx.doi.org/10.3390/ijms22042163 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rajesh, Yetirajam Sarkar, Devanand Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer |
title | Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer |
title_full | Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer |
title_fullStr | Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer |
title_full_unstemmed | Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer |
title_short | Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer |
title_sort | association of adipose tissue and adipokines with development of obesity-induced liver cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926723/ https://www.ncbi.nlm.nih.gov/pubmed/33671547 http://dx.doi.org/10.3390/ijms22042163 |
work_keys_str_mv | AT rajeshyetirajam associationofadiposetissueandadipokineswithdevelopmentofobesityinducedlivercancer AT sarkardevanand associationofadiposetissueandadipokineswithdevelopmentofobesityinducedlivercancer |