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Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists
Background: Systemic photoprotection (i.e., administration of substances such as nicotinamide, carotenoids, and vitamin D) may be important to reduce photocarcinogenesis or to support long-term protection against UV irradiation. Clinical trials showed that oral nicotinamide is effective in reducing...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926776/ https://www.ncbi.nlm.nih.gov/pubmed/33672113 http://dx.doi.org/10.3390/biom11020332 |
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author | Fania, Luca Sampogna, Francesca Ricci, Francesco Hyeraci, Mariafrancesca Paradisi, Andrea Palese, Enzo Di Lella, Giovanni Pallotta, Sabatino Panebianco, Annarita Candi, Eleonora Dellambra, Elena Abeni, Damiano |
author_facet | Fania, Luca Sampogna, Francesca Ricci, Francesco Hyeraci, Mariafrancesca Paradisi, Andrea Palese, Enzo Di Lella, Giovanni Pallotta, Sabatino Panebianco, Annarita Candi, Eleonora Dellambra, Elena Abeni, Damiano |
author_sort | Fania, Luca |
collection | PubMed |
description | Background: Systemic photoprotection (i.e., administration of substances such as nicotinamide, carotenoids, and vitamin D) may be important to reduce photocarcinogenesis or to support long-term protection against UV irradiation. Clinical trials showed that oral nicotinamide is effective in reducing the onset of new nonmelanoma skin cancers (NMSCs), while other oral photoprotectors failed to achieve the reduction of new melanoma or NMSC formation in humans. The aim of this study was to summarize the current state of knowledge of systemic photoprotection and to evaluate the knowledge and attitude of dermatologists regarding these treatments. Methods: The survey was conducted on a sample of dermatologists recruited according to a snowball sampling procedure. The questionnaire consisted of a first part asking for characteristics of the participant and a second part with 12 specific questions on their knowledge about systemic photoprotection, particularly their knowledge of astaxanthin, β-carotene, nicotinamide, and vitamin D3. Results: One hundred eight dermatologists answered the survey. Most of them (85.2%) stated that oral photoprotectors have a role in the prevention of skin cancer, and responses mainly mentioned nicotinamide. More than half of them (54.6%) had prescribed all the considered oral photoprotectors, but the majority of them had prescribed nicotinamide, mainly for 2 to 3 months during summer, almost invariably (n = 106) associated with topical photoprotectors. Most dermatologists (>80%) were aware of scientific publications demonstrating an effect of systemic photoprotectors on NMSC. Conclusions: Most Italian dermatologists have positive views on oral photoprotection in skin cancer and are aware of the demonstrated potential of nicotinamide in the prevention of NMSCs. |
format | Online Article Text |
id | pubmed-7926776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79267762021-03-04 Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists Fania, Luca Sampogna, Francesca Ricci, Francesco Hyeraci, Mariafrancesca Paradisi, Andrea Palese, Enzo Di Lella, Giovanni Pallotta, Sabatino Panebianco, Annarita Candi, Eleonora Dellambra, Elena Abeni, Damiano Biomolecules Article Background: Systemic photoprotection (i.e., administration of substances such as nicotinamide, carotenoids, and vitamin D) may be important to reduce photocarcinogenesis or to support long-term protection against UV irradiation. Clinical trials showed that oral nicotinamide is effective in reducing the onset of new nonmelanoma skin cancers (NMSCs), while other oral photoprotectors failed to achieve the reduction of new melanoma or NMSC formation in humans. The aim of this study was to summarize the current state of knowledge of systemic photoprotection and to evaluate the knowledge and attitude of dermatologists regarding these treatments. Methods: The survey was conducted on a sample of dermatologists recruited according to a snowball sampling procedure. The questionnaire consisted of a first part asking for characteristics of the participant and a second part with 12 specific questions on their knowledge about systemic photoprotection, particularly their knowledge of astaxanthin, β-carotene, nicotinamide, and vitamin D3. Results: One hundred eight dermatologists answered the survey. Most of them (85.2%) stated that oral photoprotectors have a role in the prevention of skin cancer, and responses mainly mentioned nicotinamide. More than half of them (54.6%) had prescribed all the considered oral photoprotectors, but the majority of them had prescribed nicotinamide, mainly for 2 to 3 months during summer, almost invariably (n = 106) associated with topical photoprotectors. Most dermatologists (>80%) were aware of scientific publications demonstrating an effect of systemic photoprotectors on NMSC. Conclusions: Most Italian dermatologists have positive views on oral photoprotection in skin cancer and are aware of the demonstrated potential of nicotinamide in the prevention of NMSCs. MDPI 2021-02-23 /pmc/articles/PMC7926776/ /pubmed/33672113 http://dx.doi.org/10.3390/biom11020332 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fania, Luca Sampogna, Francesca Ricci, Francesco Hyeraci, Mariafrancesca Paradisi, Andrea Palese, Enzo Di Lella, Giovanni Pallotta, Sabatino Panebianco, Annarita Candi, Eleonora Dellambra, Elena Abeni, Damiano Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists |
title | Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists |
title_full | Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists |
title_fullStr | Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists |
title_full_unstemmed | Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists |
title_short | Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists |
title_sort | systemic photoprotection in skin cancer prevention: knowledge among dermatologists |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926776/ https://www.ncbi.nlm.nih.gov/pubmed/33672113 http://dx.doi.org/10.3390/biom11020332 |
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