Synthesis and Biological Evaluation of 1-(Diarylmethyl)-1H-1,2,4-triazoles and 1-(Diarylmethyl)-1H-imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer

We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)-positive MCF-7 breast cancer cells identified 5-((2H-1,2,3-triazo...

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Detalles Bibliográficos
Autores principales: Ana, Gloria, Kelly, Patrick M., Malebari, Azizah M., Noorani, Sara, Nathwani, Seema M., Twamley, Brendan, Fayne, Darren, O’Boyle, Niamh M., Zisterer, Daniela M., Pimentel, Elisangela Flavia, Endringer, Denise Coutinho, Meegan, Mary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926793/
https://www.ncbi.nlm.nih.gov/pubmed/33671674
http://dx.doi.org/10.3390/ph14020169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926793/
https://www.ncbi.nlm.nih.gov/pubmed/33671674
http://dx.doi.org/10.3390/ph14020169

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