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Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model
Vitamin D deficiency shows positive correlation to cardiovascular risk, which might be influenced by gender specific features. Our goal was to examine the effect of Vitamin D supplementation and Vitamin D deficiency in male and female rats on an important hypertension target organ, the renal artery....
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926839/ https://www.ncbi.nlm.nih.gov/pubmed/33671779 http://dx.doi.org/10.3390/nu13020704 |
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author | Sipos, Miklós Péterffy, Borbála Sziva, Réka Eszter Magyar, Péter Hadjadj, Leila Bányai, Bálint Süli, Anita Soltész-Katona, Eszter Gerszi, Dóra Kiss, Judit Szekeres, Mária Nádasy, György L. Horváth, Eszter Mária Várbíró, Szabolcs |
author_facet | Sipos, Miklós Péterffy, Borbála Sziva, Réka Eszter Magyar, Péter Hadjadj, Leila Bányai, Bálint Süli, Anita Soltész-Katona, Eszter Gerszi, Dóra Kiss, Judit Szekeres, Mária Nádasy, György L. Horváth, Eszter Mária Várbíró, Szabolcs |
author_sort | Sipos, Miklós |
collection | PubMed |
description | Vitamin D deficiency shows positive correlation to cardiovascular risk, which might be influenced by gender specific features. Our goal was to examine the effect of Vitamin D supplementation and Vitamin D deficiency in male and female rats on an important hypertension target organ, the renal artery. Female and male Wistar rats were fed with Vitamin D reduced chow for eight weeks to induce hypovitaminosis. Another group of animals received normal chow with further supplementation to reach optimal serum vitamin levels. Isolated renal arteries of Vitamin D deficient female rats showed increased phenylephrine-induced contraction. In all experimental groups, both indomethacin and selective cyclooxygenase-2 inhibition (NS398) decreased the phenylephrine-induced contraction. Angiotensin II-induced contraction was pronounced in Vitamin D supplemented males. In both Vitamin D deficient groups, acetylcholine-induced relaxation was impaired. In the female Vitamin D supplemented group NS398, in males the indomethacin caused reduced acetylcholine-induced relaxation. Increased elastic fiber density was observed in Vitamin D deficient females. The intensity of eNOS immunostaining was decreased in Vitamin D deficient females. The density of AT(1)R staining was the highest in the male Vitamin D deficient group. Although Vitamin D deficiency induced renal vascular dysfunction in both sexes, female rats developed more extensive impairment that was accompanied by enzymatic and structural changes. |
format | Online Article Text |
id | pubmed-7926839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79268392021-03-04 Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model Sipos, Miklós Péterffy, Borbála Sziva, Réka Eszter Magyar, Péter Hadjadj, Leila Bányai, Bálint Süli, Anita Soltész-Katona, Eszter Gerszi, Dóra Kiss, Judit Szekeres, Mária Nádasy, György L. Horváth, Eszter Mária Várbíró, Szabolcs Nutrients Article Vitamin D deficiency shows positive correlation to cardiovascular risk, which might be influenced by gender specific features. Our goal was to examine the effect of Vitamin D supplementation and Vitamin D deficiency in male and female rats on an important hypertension target organ, the renal artery. Female and male Wistar rats were fed with Vitamin D reduced chow for eight weeks to induce hypovitaminosis. Another group of animals received normal chow with further supplementation to reach optimal serum vitamin levels. Isolated renal arteries of Vitamin D deficient female rats showed increased phenylephrine-induced contraction. In all experimental groups, both indomethacin and selective cyclooxygenase-2 inhibition (NS398) decreased the phenylephrine-induced contraction. Angiotensin II-induced contraction was pronounced in Vitamin D supplemented males. In both Vitamin D deficient groups, acetylcholine-induced relaxation was impaired. In the female Vitamin D supplemented group NS398, in males the indomethacin caused reduced acetylcholine-induced relaxation. Increased elastic fiber density was observed in Vitamin D deficient females. The intensity of eNOS immunostaining was decreased in Vitamin D deficient females. The density of AT(1)R staining was the highest in the male Vitamin D deficient group. Although Vitamin D deficiency induced renal vascular dysfunction in both sexes, female rats developed more extensive impairment that was accompanied by enzymatic and structural changes. MDPI 2021-02-22 /pmc/articles/PMC7926839/ /pubmed/33671779 http://dx.doi.org/10.3390/nu13020704 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sipos, Miklós Péterffy, Borbála Sziva, Réka Eszter Magyar, Péter Hadjadj, Leila Bányai, Bálint Süli, Anita Soltész-Katona, Eszter Gerszi, Dóra Kiss, Judit Szekeres, Mária Nádasy, György L. Horváth, Eszter Mária Várbíró, Szabolcs Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model |
title | Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model |
title_full | Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model |
title_fullStr | Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model |
title_full_unstemmed | Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model |
title_short | Vitamin D Deficiency Cause Gender Specific Alterations of Renal Arterial Function in a Rodent Model |
title_sort | vitamin d deficiency cause gender specific alterations of renal arterial function in a rodent model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926839/ https://www.ncbi.nlm.nih.gov/pubmed/33671779 http://dx.doi.org/10.3390/nu13020704 |
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