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YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity

The type III secretion system effector proteins NleB and SseK are glycosyltransferases that glycosylate protein substrates on arginine residues. We conducted high-throughput screening assays on 42,498 compounds to identify NleB/SseK inhibitors. Such small molecules may be useful as mechanistic probe...

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Detalles Bibliográficos
Autores principales:	Zhu, Congrui, El Qaidi, Samir, McDonald, Peter, Roy, Anuradha, Hardwidge, Philip R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926936/ https://www.ncbi.nlm.nih.gov/pubmed/33672424 http://dx.doi.org/10.3390/pathogens10020253

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