GBA Mutations Influence the Release and Pathological Effects of Small Extracellular Vesicles from Fibroblasts of Patients with Parkinson’s Disease

Heterozygous mutations in the GBA gene, encoding the lysosomal enzyme glucocerebrosidase (GCase), are the strongest known genetic risk factor for Parkinson’s disease (PD). The molecular mechanisms underlying the increased PD risk and the variable phenotypes observed in carriers of different GBA muta...

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Detalles Bibliográficos
Autores principales: Cerri, Silvia, Ghezzi, Cristina, Ongari, Gerardo, Croce, Stefania, Avenali, Micol, Zangaglia, Roberta, Di Monte, Donato A., Valente, Enza Maria, Blandini, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927041/
https://www.ncbi.nlm.nih.gov/pubmed/33672321
http://dx.doi.org/10.3390/ijms22042215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927041/
https://www.ncbi.nlm.nih.gov/pubmed/33672321
http://dx.doi.org/10.3390/ijms22042215

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