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A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications
Propolis is a resinous substance produced by bees that exhibits antimicrobial, immunostimulatory and antioxidant activity. Its use is common in functional foods, cosmetics and traditional medicine despite the fact that it demonstrates low extraction yields and inconsistency in non-toxic solvents. In...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927051/ https://www.ncbi.nlm.nih.gov/pubmed/33672417 http://dx.doi.org/10.3390/plants10020420 |
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author | Spanidi, Eleni Karapetsas, Athanasios Voulgaridou, Georgia-Persephoni Letsiou, Sophia Aligiannis, Nektarios Tsochantaridis, Ilias Kynigopoulos, Spyridon Lambropoulou, Maria Mourtzinos, Ioannis Pappa, Aglaia Gardikis, Konstantinos |
author_facet | Spanidi, Eleni Karapetsas, Athanasios Voulgaridou, Georgia-Persephoni Letsiou, Sophia Aligiannis, Nektarios Tsochantaridis, Ilias Kynigopoulos, Spyridon Lambropoulou, Maria Mourtzinos, Ioannis Pappa, Aglaia Gardikis, Konstantinos |
author_sort | Spanidi, Eleni |
collection | PubMed |
description | Propolis is a resinous substance produced by bees that exhibits antimicrobial, immunostimulatory and antioxidant activity. Its use is common in functional foods, cosmetics and traditional medicine despite the fact that it demonstrates low extraction yields and inconsistency in non-toxic solvents. In this work, a new encapsulation and delivery system consisting of liposomes and cyclodextrins incorporating propolis polyphenols has been developed and characterized. The antioxidant, antimutagenic and antiaging properties of the system under normal and UVB-induced oxidative stress conditions were investigated in cultured skin cells and/or reconstituted skin model. Furthermore, the transcript accumulation for an array of genes involved in many skin-related processes was studied. The system exhibits significant polyphenol encapsulation efficiency, physicochemical stability as well as controlled release rate in appropriate conditions. The delivery system can retain the anti-mutagenic, anti-oxidative and anti-ageing effects of propolis polyphenols to levels similar and comparable to those of propolis methanolic extracts, making the system ideal for applications where non-toxic solvents are required and controlled release of the polyphenol content is desired. |
format | Online Article Text |
id | pubmed-7927051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79270512021-03-04 A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications Spanidi, Eleni Karapetsas, Athanasios Voulgaridou, Georgia-Persephoni Letsiou, Sophia Aligiannis, Nektarios Tsochantaridis, Ilias Kynigopoulos, Spyridon Lambropoulou, Maria Mourtzinos, Ioannis Pappa, Aglaia Gardikis, Konstantinos Plants (Basel) Article Propolis is a resinous substance produced by bees that exhibits antimicrobial, immunostimulatory and antioxidant activity. Its use is common in functional foods, cosmetics and traditional medicine despite the fact that it demonstrates low extraction yields and inconsistency in non-toxic solvents. In this work, a new encapsulation and delivery system consisting of liposomes and cyclodextrins incorporating propolis polyphenols has been developed and characterized. The antioxidant, antimutagenic and antiaging properties of the system under normal and UVB-induced oxidative stress conditions were investigated in cultured skin cells and/or reconstituted skin model. Furthermore, the transcript accumulation for an array of genes involved in many skin-related processes was studied. The system exhibits significant polyphenol encapsulation efficiency, physicochemical stability as well as controlled release rate in appropriate conditions. The delivery system can retain the anti-mutagenic, anti-oxidative and anti-ageing effects of propolis polyphenols to levels similar and comparable to those of propolis methanolic extracts, making the system ideal for applications where non-toxic solvents are required and controlled release of the polyphenol content is desired. MDPI 2021-02-23 /pmc/articles/PMC7927051/ /pubmed/33672417 http://dx.doi.org/10.3390/plants10020420 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Spanidi, Eleni Karapetsas, Athanasios Voulgaridou, Georgia-Persephoni Letsiou, Sophia Aligiannis, Nektarios Tsochantaridis, Ilias Kynigopoulos, Spyridon Lambropoulou, Maria Mourtzinos, Ioannis Pappa, Aglaia Gardikis, Konstantinos A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications |
title | A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications |
title_full | A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications |
title_fullStr | A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications |
title_full_unstemmed | A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications |
title_short | A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications |
title_sort | new controlled release system for propolis polyphenols and its biochemical activity for skin applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927051/ https://www.ncbi.nlm.nih.gov/pubmed/33672417 http://dx.doi.org/10.3390/plants10020420 |
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