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The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases

Hydrogen sulfide (H(2)S) has long been considered as a toxic gas, but as research progressed, the idea has been updated and it has now been shown to have potent protective effects at reasonable concentrations. H(2)S is an endogenous gas signaling molecule in mammals and is produced by specific enzym...

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Autores principales: Wang, Yi-Zhen, Ngowi, Ebenezeri Erasto, Wang, Di, Qi, Hui-Wen, Jing, Mi-Rong, Zhang, Yan-Xia, Cai, Chun-Bo, He, Qing-Lin, Khattak, Saadullah, Khan, Nazeer Hussain, Jiang, Qi-Ying, Ji, Xin-Ying, Wu, Dong-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927090/
https://www.ncbi.nlm.nih.gov/pubmed/33672103
http://dx.doi.org/10.3390/ijms22042194
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author Wang, Yi-Zhen
Ngowi, Ebenezeri Erasto
Wang, Di
Qi, Hui-Wen
Jing, Mi-Rong
Zhang, Yan-Xia
Cai, Chun-Bo
He, Qing-Lin
Khattak, Saadullah
Khan, Nazeer Hussain
Jiang, Qi-Ying
Ji, Xin-Ying
Wu, Dong-Dong
author_facet Wang, Yi-Zhen
Ngowi, Ebenezeri Erasto
Wang, Di
Qi, Hui-Wen
Jing, Mi-Rong
Zhang, Yan-Xia
Cai, Chun-Bo
He, Qing-Lin
Khattak, Saadullah
Khan, Nazeer Hussain
Jiang, Qi-Ying
Ji, Xin-Ying
Wu, Dong-Dong
author_sort Wang, Yi-Zhen
collection PubMed
description Hydrogen sulfide (H(2)S) has long been considered as a toxic gas, but as research progressed, the idea has been updated and it has now been shown to have potent protective effects at reasonable concentrations. H(2)S is an endogenous gas signaling molecule in mammals and is produced by specific enzymes in different cell types. An increasing number of studies indicate that H(2)S plays an important role in cardiovascular homeostasis, and in most cases, H(2)S has been reported to be downregulated in cardiovascular diseases (CVDs). Similarly, in preclinical studies, H(2)S has been shown to prevent CVDs and improve heart function after heart failure. Recently, many H(2)S donors have been synthesized and tested in cellular and animal models. Moreover, numerous molecular mechanisms have been proposed to demonstrate the effects of these donors. In this review, we will provide an update on the role of H(2)S in cardiovascular activities and its involvement in pathological states, with a special focus on the roles of exogenous H(2)S in cardiac protection.
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spelling pubmed-79270902021-03-04 The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases Wang, Yi-Zhen Ngowi, Ebenezeri Erasto Wang, Di Qi, Hui-Wen Jing, Mi-Rong Zhang, Yan-Xia Cai, Chun-Bo He, Qing-Lin Khattak, Saadullah Khan, Nazeer Hussain Jiang, Qi-Ying Ji, Xin-Ying Wu, Dong-Dong Int J Mol Sci Review Hydrogen sulfide (H(2)S) has long been considered as a toxic gas, but as research progressed, the idea has been updated and it has now been shown to have potent protective effects at reasonable concentrations. H(2)S is an endogenous gas signaling molecule in mammals and is produced by specific enzymes in different cell types. An increasing number of studies indicate that H(2)S plays an important role in cardiovascular homeostasis, and in most cases, H(2)S has been reported to be downregulated in cardiovascular diseases (CVDs). Similarly, in preclinical studies, H(2)S has been shown to prevent CVDs and improve heart function after heart failure. Recently, many H(2)S donors have been synthesized and tested in cellular and animal models. Moreover, numerous molecular mechanisms have been proposed to demonstrate the effects of these donors. In this review, we will provide an update on the role of H(2)S in cardiovascular activities and its involvement in pathological states, with a special focus on the roles of exogenous H(2)S in cardiac protection. MDPI 2021-02-23 /pmc/articles/PMC7927090/ /pubmed/33672103 http://dx.doi.org/10.3390/ijms22042194 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Yi-Zhen
Ngowi, Ebenezeri Erasto
Wang, Di
Qi, Hui-Wen
Jing, Mi-Rong
Zhang, Yan-Xia
Cai, Chun-Bo
He, Qing-Lin
Khattak, Saadullah
Khan, Nazeer Hussain
Jiang, Qi-Ying
Ji, Xin-Ying
Wu, Dong-Dong
The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases
title The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases
title_full The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases
title_fullStr The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases
title_full_unstemmed The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases
title_short The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases
title_sort potential of hydrogen sulfide donors in treating cardiovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927090/
https://www.ncbi.nlm.nih.gov/pubmed/33672103
http://dx.doi.org/10.3390/ijms22042194
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