Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases

[Image: see text] Multidrug resistant Gram-negative bacterial infections are an increasing public health threat due to rapidly rising resistance toward β-lactam antibiotics. The hydrolytic enzymes called β-lactamases are responsible for a large proportion of the resistance phenotype. β-Lactamase inh...

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Detalles Bibliográficos
Autores principales: Durand-Réville, Thomas F., Comita-Prevoir, Janelle, Zhang, Jing, Wu, Xiaoyun, May-Dracka, Tricia L., Romero, Jan Antoinette C., Wu, Frank, Chen, April, Shapiro, Adam B., Carter, Nicole M., McLeod, Sarah M., Giacobbe, Robert A., Verheijen, Jeroen C., Lahiri, Sushmita D., Sacco, Michael D., Chen, Yu, O’Donnell, John P., Miller, Alita A., Mueller, John P., Tommasi, Rubén A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927146/
https://www.ncbi.nlm.nih.gov/pubmed/32658473
http://dx.doi.org/10.1021/acs.jmedchem.0c00579

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