Cargando…

Probing the role of the right inferior frontal gyrus during Pain‐Related empathy processing: Evidence from fMRI and TMS

Recent studies have suggested that the right inferior frontal gyrus (rIFG) may be involved in pain‐related empathy. To verify the role of the rIFG, we performed a functional magnetic resonance imaging (fMRI) experiment to replicate previous research and further designed a noninvasive repetitive tran...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yun, Li, Wenjuan, Zhang, Tingting, Zhang, Junjun, Jin, Zhenlan, Li, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927301/
https://www.ncbi.nlm.nih.gov/pubmed/33283946
http://dx.doi.org/10.1002/hbm.25310
_version_ 1783659650502098944
author Li, Yun
Li, Wenjuan
Zhang, Tingting
Zhang, Junjun
Jin, Zhenlan
Li, Ling
author_facet Li, Yun
Li, Wenjuan
Zhang, Tingting
Zhang, Junjun
Jin, Zhenlan
Li, Ling
author_sort Li, Yun
collection PubMed
description Recent studies have suggested that the right inferior frontal gyrus (rIFG) may be involved in pain‐related empathy. To verify the role of the rIFG, we performed a functional magnetic resonance imaging (fMRI) experiment to replicate previous research and further designed a noninvasive repetitive transcranial magnetic stimulation (rTMS) experiment to probe the causal role of the rIFG in pain‐related empathy processing. We assigned 74 volunteers (37 females) to three groups. Group 1 (n = 26) performed a task in which participants were required to perceive pain in others (task of pain: TP) and we used fMRI to observe the activity of the rIFG during pain‐related empathy processing. Then, we applied online rTMS to the rIFG and the vertex site (as reference site) to observe the performance of Group 2 (n = 24; performing TP) and Group 3 (n = 24; performing a control task of identifying body parts; task of body: TB). fMRI experiment demonstrated stronger activation in the rIFG than in the vertex during the perception of pain in others (p < .0001, Bonferroni‐corrected). rTMS experiment indicated that when the rIFG was temporarily disrupted, participants perceived pain in others significantly more slowly (p < .0001, Bonferroni‐corrected) than when the vertex was disrupted. Our results provide evidence that the rIFG is involved in pain‐related empathy processing, which yields insights into how the brain perceives pain in others.
format Online
Article
Text
id pubmed-7927301
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-79273012021-03-12 Probing the role of the right inferior frontal gyrus during Pain‐Related empathy processing: Evidence from fMRI and TMS Li, Yun Li, Wenjuan Zhang, Tingting Zhang, Junjun Jin, Zhenlan Li, Ling Hum Brain Mapp Research Articles Recent studies have suggested that the right inferior frontal gyrus (rIFG) may be involved in pain‐related empathy. To verify the role of the rIFG, we performed a functional magnetic resonance imaging (fMRI) experiment to replicate previous research and further designed a noninvasive repetitive transcranial magnetic stimulation (rTMS) experiment to probe the causal role of the rIFG in pain‐related empathy processing. We assigned 74 volunteers (37 females) to three groups. Group 1 (n = 26) performed a task in which participants were required to perceive pain in others (task of pain: TP) and we used fMRI to observe the activity of the rIFG during pain‐related empathy processing. Then, we applied online rTMS to the rIFG and the vertex site (as reference site) to observe the performance of Group 2 (n = 24; performing TP) and Group 3 (n = 24; performing a control task of identifying body parts; task of body: TB). fMRI experiment demonstrated stronger activation in the rIFG than in the vertex during the perception of pain in others (p < .0001, Bonferroni‐corrected). rTMS experiment indicated that when the rIFG was temporarily disrupted, participants perceived pain in others significantly more slowly (p < .0001, Bonferroni‐corrected) than when the vertex was disrupted. Our results provide evidence that the rIFG is involved in pain‐related empathy processing, which yields insights into how the brain perceives pain in others. John Wiley & Sons, Inc. 2020-12-07 /pmc/articles/PMC7927301/ /pubmed/33283946 http://dx.doi.org/10.1002/hbm.25310 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Li, Yun
Li, Wenjuan
Zhang, Tingting
Zhang, Junjun
Jin, Zhenlan
Li, Ling
Probing the role of the right inferior frontal gyrus during Pain‐Related empathy processing: Evidence from fMRI and TMS
title Probing the role of the right inferior frontal gyrus during Pain‐Related empathy processing: Evidence from fMRI and TMS
title_full Probing the role of the right inferior frontal gyrus during Pain‐Related empathy processing: Evidence from fMRI and TMS
title_fullStr Probing the role of the right inferior frontal gyrus during Pain‐Related empathy processing: Evidence from fMRI and TMS
title_full_unstemmed Probing the role of the right inferior frontal gyrus during Pain‐Related empathy processing: Evidence from fMRI and TMS
title_short Probing the role of the right inferior frontal gyrus during Pain‐Related empathy processing: Evidence from fMRI and TMS
title_sort probing the role of the right inferior frontal gyrus during pain‐related empathy processing: evidence from fmri and tms
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927301/
https://www.ncbi.nlm.nih.gov/pubmed/33283946
http://dx.doi.org/10.1002/hbm.25310
work_keys_str_mv AT liyun probingtheroleoftherightinferiorfrontalgyrusduringpainrelatedempathyprocessingevidencefromfmriandtms
AT liwenjuan probingtheroleoftherightinferiorfrontalgyrusduringpainrelatedempathyprocessingevidencefromfmriandtms
AT zhangtingting probingtheroleoftherightinferiorfrontalgyrusduringpainrelatedempathyprocessingevidencefromfmriandtms
AT zhangjunjun probingtheroleoftherightinferiorfrontalgyrusduringpainrelatedempathyprocessingevidencefromfmriandtms
AT jinzhenlan probingtheroleoftherightinferiorfrontalgyrusduringpainrelatedempathyprocessingevidencefromfmriandtms
AT liling probingtheroleoftherightinferiorfrontalgyrusduringpainrelatedempathyprocessingevidencefromfmriandtms