Cargando…
Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis
Previous literature about the structural characterization of the human cerebellum is related to the context of a specific pathology or focused in a restricted age range. In fact, studies about the cerebellum maturation across the lifespan are scarce and most of them considered the cerebellum as a wh...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927303/ https://www.ncbi.nlm.nih.gov/pubmed/33385303 http://dx.doi.org/10.1002/hbm.25293 |
_version_ | 1783659650983395328 |
---|---|
author | Romero, José E. Coupe, Pierrick Lanuza, Enrique Catheline, Gwenaelle Manjón, José V. |
author_facet | Romero, José E. Coupe, Pierrick Lanuza, Enrique Catheline, Gwenaelle Manjón, José V. |
author_sort | Romero, José E. |
collection | PubMed |
description | Previous literature about the structural characterization of the human cerebellum is related to the context of a specific pathology or focused in a restricted age range. In fact, studies about the cerebellum maturation across the lifespan are scarce and most of them considered the cerebellum as a whole without investigating each lobule. This lack of study can be explained by the lack of both accurate segmentation methods and data availability. Fortunately, during the last years, several cerebellum segmentation methods have been developed and many databases comprising subjects of different ages have been made publically available. This fact opens an opportunity window to obtain a more extensive analysis of the cerebellum maturation and aging. In this study, we have used a recent state‐of‐the‐art cerebellum segmentation method called CERES and a large data set (N = 2,831 images) from healthy controls covering the entire lifespan to provide a model for 12 cerebellum structures (i.e., lobules I‐II, III, IV, VI, Crus I, Crus II, VIIB, VIIIA, VIIIB, IX, and X). We found that lobules have generally an evolution that follows a trajectory composed by a fast growth and a slow degeneration having sometimes a plateau for absolute volumes, and a decreasing tendency (faster in early ages) for normalized volumes. Special consideration is dedicated to Crus II, where slow degeneration appears to stabilize in elder ages for absolute volumes, and to lobule X, which does not present any fast growth during childhood in absolute volumes and shows a slow growth for normalized volumes. |
format | Online Article Text |
id | pubmed-7927303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79273032021-03-12 Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis Romero, José E. Coupe, Pierrick Lanuza, Enrique Catheline, Gwenaelle Manjón, José V. Hum Brain Mapp Research Articles Previous literature about the structural characterization of the human cerebellum is related to the context of a specific pathology or focused in a restricted age range. In fact, studies about the cerebellum maturation across the lifespan are scarce and most of them considered the cerebellum as a whole without investigating each lobule. This lack of study can be explained by the lack of both accurate segmentation methods and data availability. Fortunately, during the last years, several cerebellum segmentation methods have been developed and many databases comprising subjects of different ages have been made publically available. This fact opens an opportunity window to obtain a more extensive analysis of the cerebellum maturation and aging. In this study, we have used a recent state‐of‐the‐art cerebellum segmentation method called CERES and a large data set (N = 2,831 images) from healthy controls covering the entire lifespan to provide a model for 12 cerebellum structures (i.e., lobules I‐II, III, IV, VI, Crus I, Crus II, VIIB, VIIIA, VIIIB, IX, and X). We found that lobules have generally an evolution that follows a trajectory composed by a fast growth and a slow degeneration having sometimes a plateau for absolute volumes, and a decreasing tendency (faster in early ages) for normalized volumes. Special consideration is dedicated to Crus II, where slow degeneration appears to stabilize in elder ages for absolute volumes, and to lobule X, which does not present any fast growth during childhood in absolute volumes and shows a slow growth for normalized volumes. John Wiley & Sons, Inc. 2021-01-01 /pmc/articles/PMC7927303/ /pubmed/33385303 http://dx.doi.org/10.1002/hbm.25293 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Romero, José E. Coupe, Pierrick Lanuza, Enrique Catheline, Gwenaelle Manjón, José V. Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis |
title | Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis |
title_full | Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis |
title_fullStr | Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis |
title_full_unstemmed | Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis |
title_short | Toward a unified analysis of cerebellum maturation and aging across the entire lifespan: A MRI analysis |
title_sort | toward a unified analysis of cerebellum maturation and aging across the entire lifespan: a mri analysis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927303/ https://www.ncbi.nlm.nih.gov/pubmed/33385303 http://dx.doi.org/10.1002/hbm.25293 |
work_keys_str_mv | AT romerojosee towardaunifiedanalysisofcerebellummaturationandagingacrosstheentirelifespanamrianalysis AT coupepierrick towardaunifiedanalysisofcerebellummaturationandagingacrosstheentirelifespanamrianalysis AT lanuzaenrique towardaunifiedanalysisofcerebellummaturationandagingacrosstheentirelifespanamrianalysis AT cathelinegwenaelle towardaunifiedanalysisofcerebellummaturationandagingacrosstheentirelifespanamrianalysis AT manjonjosev towardaunifiedanalysisofcerebellummaturationandagingacrosstheentirelifespanamrianalysis AT towardaunifiedanalysisofcerebellummaturationandagingacrosstheentirelifespanamrianalysis |