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SPRED1 deletion confers resistance to MAPK inhibition in melanoma

Functional evaluation of genetic lesions can discover a role in cancer initiation and progression and help develop novel therapeutic strategies. We previously identified the negative MAPK regulator SPRED1 as a novel tumor suppressor in KIT-driven melanoma. Here, we show that SPRED1 is also frequentl...

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Detalles Bibliográficos
Autores principales:	Ablain, Julien, Liu, Sixue, Moriceau, Gatien, Lo, Roger S., Zon, Leonard I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927430/ https://www.ncbi.nlm.nih.gov/pubmed/33306107 http://dx.doi.org/10.1084/jem.20201097

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