Cargando…
Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine
Opioid and cannabinoid systems have considerable roles in the modulation of chronic pain as well as regulation reward circuit and addiction responses. This study investigated the effect of nitroglycerin (NTG)-induced migraine attack on the acquisition of morphine and cannabinoid-induced conditioned...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mattioli 1885
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927472/ https://www.ncbi.nlm.nih.gov/pubmed/33525279 http://dx.doi.org/10.23750/abm.v91i4.8799 |
_version_ | 1783659675426750464 |
---|---|
author | Mansoori, Mojdeh Zarei, Mohammad Reza Chamani, Goli Nazeri, Masoud Mohammadi, Fatemeh Alavi, Samane Sadat Shabani, Mohammad |
author_facet | Mansoori, Mojdeh Zarei, Mohammad Reza Chamani, Goli Nazeri, Masoud Mohammadi, Fatemeh Alavi, Samane Sadat Shabani, Mohammad |
author_sort | Mansoori, Mojdeh |
collection | PubMed |
description | Opioid and cannabinoid systems have considerable roles in the modulation of chronic pain as well as regulation reward circuit and addiction responses. This study investigated the effect of nitroglycerin (NTG)-induced migraine attack on the acquisition of morphine and cannabinoid-induced conditioned place preference (CPP) in male rats. Adult male rats (230-250 gr) were used. Experimental groups were included (n=10): control, opioid receptor agonist morphine (10 mg/kg), WIN55,212-2 (1 mg/kg) as a cannabinoid receptor agonist, NTG + morphine (10 mg/kg) and NTG + WIN55,212-2 (1 mg/kg). Nitroglycerin (10 mg/kg) was used to induce migraine attacks every other day for 9 days. After migraine induction, conditioning performance was assessed by CPP test. During conditioning days, morphine and WIN55,212-2 were injected subcutaneously and intraperitoneally, respectively. Anxiety and locomotor activity were evaluated using open field test (OFT). According to data, conditioning score for morphine-treated rats was significantly decreased following NTG-induced migraine (p<0.01). However, NTG-induced migraine was able to increase the conditioning score in WIN55,212-2 as compared to the control group (p<0.05). In OFT, there were no significant differences in locomotor activity and grooming behaviors between experimental groups. However, time spent in the center of the OFT box was significantly decreased in NTG plus morphine-treated rats as compared to control (p<0.05). Moreover, rearing response in NTG - treated groups which received either morphine or WIN55,212-2 decreased as compared to the control group (p<0.01). NTG induced migraine prompts a decrease in morphine and an increase in cannabinoid performances. So, these compounds’ effects on drug dependency during migraine attacks may occur at different mechanisms. (www.actabiomedica.it) |
format | Online Article Text |
id | pubmed-7927472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-79274722021-03-04 Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine Mansoori, Mojdeh Zarei, Mohammad Reza Chamani, Goli Nazeri, Masoud Mohammadi, Fatemeh Alavi, Samane Sadat Shabani, Mohammad Acta Biomed Original Article Opioid and cannabinoid systems have considerable roles in the modulation of chronic pain as well as regulation reward circuit and addiction responses. This study investigated the effect of nitroglycerin (NTG)-induced migraine attack on the acquisition of morphine and cannabinoid-induced conditioned place preference (CPP) in male rats. Adult male rats (230-250 gr) were used. Experimental groups were included (n=10): control, opioid receptor agonist morphine (10 mg/kg), WIN55,212-2 (1 mg/kg) as a cannabinoid receptor agonist, NTG + morphine (10 mg/kg) and NTG + WIN55,212-2 (1 mg/kg). Nitroglycerin (10 mg/kg) was used to induce migraine attacks every other day for 9 days. After migraine induction, conditioning performance was assessed by CPP test. During conditioning days, morphine and WIN55,212-2 were injected subcutaneously and intraperitoneally, respectively. Anxiety and locomotor activity were evaluated using open field test (OFT). According to data, conditioning score for morphine-treated rats was significantly decreased following NTG-induced migraine (p<0.01). However, NTG-induced migraine was able to increase the conditioning score in WIN55,212-2 as compared to the control group (p<0.05). In OFT, there were no significant differences in locomotor activity and grooming behaviors between experimental groups. However, time spent in the center of the OFT box was significantly decreased in NTG plus morphine-treated rats as compared to control (p<0.05). Moreover, rearing response in NTG - treated groups which received either morphine or WIN55,212-2 decreased as compared to the control group (p<0.01). NTG induced migraine prompts a decrease in morphine and an increase in cannabinoid performances. So, these compounds’ effects on drug dependency during migraine attacks may occur at different mechanisms. (www.actabiomedica.it) Mattioli 1885 2020 2020-12-21 /pmc/articles/PMC7927472/ /pubmed/33525279 http://dx.doi.org/10.23750/abm.v91i4.8799 Text en Copyright: © 2020 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Original Article Mansoori, Mojdeh Zarei, Mohammad Reza Chamani, Goli Nazeri, Masoud Mohammadi, Fatemeh Alavi, Samane Sadat Shabani, Mohammad Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine |
title | Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine |
title_full | Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine |
title_fullStr | Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine |
title_full_unstemmed | Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine |
title_short | Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine |
title_sort | chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927472/ https://www.ncbi.nlm.nih.gov/pubmed/33525279 http://dx.doi.org/10.23750/abm.v91i4.8799 |
work_keys_str_mv | AT mansoorimojdeh chronicmigrainecausedahigherrateoftendencytocannabinoidagonistcomparedtomorphine AT zareimohammadreza chronicmigrainecausedahigherrateoftendencytocannabinoidagonistcomparedtomorphine AT chamanigoli chronicmigrainecausedahigherrateoftendencytocannabinoidagonistcomparedtomorphine AT nazerimasoud chronicmigrainecausedahigherrateoftendencytocannabinoidagonistcomparedtomorphine AT mohammadifatemeh chronicmigrainecausedahigherrateoftendencytocannabinoidagonistcomparedtomorphine AT alavisamanesadat chronicmigrainecausedahigherrateoftendencytocannabinoidagonistcomparedtomorphine AT shabanimohammad chronicmigrainecausedahigherrateoftendencytocannabinoidagonistcomparedtomorphine |