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Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency

Pathogen reduction technologies (PRT) have been recommended by many regulatory authorities to minimize the residual risk of transfusion-transmitted infections associated with COVID19 convalescent plasma. While its impact on safety and its cost-effectiveness are nowadays well proven, there is theoret...

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Detalles Bibliográficos
Autores principales: Focosi, D., Franchini, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Société française de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927574/
https://www.ncbi.nlm.nih.gov/pubmed/33675992
http://dx.doi.org/10.1016/j.tracli.2021.02.005
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author Focosi, D.
Franchini, M.
author_facet Focosi, D.
Franchini, M.
author_sort Focosi, D.
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description Pathogen reduction technologies (PRT) have been recommended by many regulatory authorities to minimize the residual risk of transfusion-transmitted infections associated with COVID19 convalescent plasma. While its impact on safety and its cost-effectiveness are nowadays well proven, there is theoretical concern that PRT could impact efficacy of convalescent plasma by altering concentration and/or function of the neutralizing antibodies (nAb). We review here the evidence supporting a lack of significant detrimental effect from PRTs on nAbs.
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spelling pubmed-79275742021-03-04 Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency Focosi, D. Franchini, M. Transfus Clin Biol Editorial Pathogen reduction technologies (PRT) have been recommended by many regulatory authorities to minimize the residual risk of transfusion-transmitted infections associated with COVID19 convalescent plasma. While its impact on safety and its cost-effectiveness are nowadays well proven, there is theoretical concern that PRT could impact efficacy of convalescent plasma by altering concentration and/or function of the neutralizing antibodies (nAb). We review here the evidence supporting a lack of significant detrimental effect from PRTs on nAbs. Société française de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. 2021-05 2021-03-03 /pmc/articles/PMC7927574/ /pubmed/33675992 http://dx.doi.org/10.1016/j.tracli.2021.02.005 Text en © 2021 Société française de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Editorial
Focosi, D.
Franchini, M.
Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency
title Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency
title_full Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency
title_fullStr Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency
title_full_unstemmed Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency
title_short Impact of pathogen-reduction technologies on COVID-19 convalescent plasma potency
title_sort impact of pathogen-reduction technologies on covid-19 convalescent plasma potency
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927574/
https://www.ncbi.nlm.nih.gov/pubmed/33675992
http://dx.doi.org/10.1016/j.tracli.2021.02.005
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