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Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a major public health threat worldwide. Insight into protective and pathogenic aspects of SARS-CoV-2 immune responses is critical to work out effective therapeutics and...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927650/ http://dx.doi.org/10.1016/j.fmre.2021.03.001 |
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author | Zhu, Airu Chen, Zhao Wang, Yanqun Zeng, Qiuhui Sun, Jing Zhuang, Zhen Li, Fang Zhao, Jingxian Zhao, Jincun Zhong, Nanshan |
author_facet | Zhu, Airu Chen, Zhao Wang, Yanqun Zeng, Qiuhui Sun, Jing Zhuang, Zhen Li, Fang Zhao, Jingxian Zhao, Jincun Zhong, Nanshan |
author_sort | Zhu, Airu |
collection | PubMed |
description | The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a major public health threat worldwide. Insight into protective and pathogenic aspects of SARS-CoV-2 immune responses is critical to work out effective therapeutics and develop vaccines for controlling the disease. Here, we review the present literature describing the innate and adaptive immune responses including innate immune cells, cytokine responses, antibody responses and T cell responses against SARS-CoV-2 in human infection, as well as in AEC2-humanized mouse infection. We also summarize the now known and unknown about the role of the SARS-CoV-2 immune responses. By better understanding the mechanisms that drive the immune responses, we can tailor treatment strategies at specific disease stages and improve our response to this worldwide public health threat. |
format | Online Article Text |
id | pubmed-7927650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79276502021-03-04 Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice Zhu, Airu Chen, Zhao Wang, Yanqun Zeng, Qiuhui Sun, Jing Zhuang, Zhen Li, Fang Zhao, Jingxian Zhao, Jincun Zhong, Nanshan Fundamental Research Review The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a major public health threat worldwide. Insight into protective and pathogenic aspects of SARS-CoV-2 immune responses is critical to work out effective therapeutics and develop vaccines for controlling the disease. Here, we review the present literature describing the innate and adaptive immune responses including innate immune cells, cytokine responses, antibody responses and T cell responses against SARS-CoV-2 in human infection, as well as in AEC2-humanized mouse infection. We also summarize the now known and unknown about the role of the SARS-CoV-2 immune responses. By better understanding the mechanisms that drive the immune responses, we can tailor treatment strategies at specific disease stages and improve our response to this worldwide public health threat. The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2021-03 2021-03-03 /pmc/articles/PMC7927650/ http://dx.doi.org/10.1016/j.fmre.2021.03.001 Text en © 2021 The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Zhu, Airu Chen, Zhao Wang, Yanqun Zeng, Qiuhui Sun, Jing Zhuang, Zhen Li, Fang Zhao, Jingxian Zhao, Jincun Zhong, Nanshan Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice |
title | Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice |
title_full | Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice |
title_fullStr | Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice |
title_full_unstemmed | Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice |
title_short | Immune responses to SARS-CoV-2 infection in Humans and ACE2 humanized mice |
title_sort | immune responses to sars-cov-2 infection in humans and ace2 humanized mice |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927650/ http://dx.doi.org/10.1016/j.fmre.2021.03.001 |
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