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Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma

Background: Metastatic brain tumors typically arise from primary malignancies of the lung, kidney, breast, skin, and colorectum. Brain metastases originating from malignancies of the female genital tract are extremely rare. We present a case of fallopian tube brain metastasis and in so doing review...

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Autores principales: Jang, Anthony I., Bernstock, Joshua D., Segar, David J., Distasio, Marcello, Matulonis, Ursula, Bi, Wenya Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927667/
https://www.ncbi.nlm.nih.gov/pubmed/33681280
http://dx.doi.org/10.3389/fsurg.2021.594570
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author Jang, Anthony I.
Bernstock, Joshua D.
Segar, David J.
Distasio, Marcello
Matulonis, Ursula
Bi, Wenya Linda
author_facet Jang, Anthony I.
Bernstock, Joshua D.
Segar, David J.
Distasio, Marcello
Matulonis, Ursula
Bi, Wenya Linda
author_sort Jang, Anthony I.
collection PubMed
description Background: Metastatic brain tumors typically arise from primary malignancies of the lung, kidney, breast, skin, and colorectum. Brain metastases originating from malignancies of the female genital tract are extremely rare. We present a case of fallopian tube brain metastasis and in so doing review the pertinent literature. Case Description: We describe a 59-year-old patient with a history of fallopian tube carcinoma who presented with an incidentally identified left frontal brain mass. MRI demonstrated an enhancing lesion in the left centrum semiovale with a second enhancing lesion noted in the cerebellar vermis. She underwent a left parietal craniotomy for resection of the dominant and clinically symptomatic lesion. Immunohistochemical stains were positive for PAX8 and p53, confirming fallopian tube origin. Conclusions: Fallopian tube cancer brain metastasis is extremely uncommon. We highlight the treatment and surgical resection of this patient's BRCA1 metastatic fallopian lesion and systematically review the literature regarding the pathogenesis, diagnosis, treatment, and histologic characteristics of the previously identified fallopian tube metastases to the central nervous system. The optimal course of treatment for brain metastasis of fallopian tube carcinoma has not been clearly defined due in part to the rarity of this condition. Consistent with BRCA1 neoplasms involving the breast and ovaries, the BRCA1 status of the patient's primary tumor likely increased the risk of central nervous system dissemination. This highlights a potential benefit of early screening of individuals with metastatic gynecologic malignancies associated with BRCA1 in the absence of any neurological symptoms.
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spelling pubmed-79276672021-03-04 Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma Jang, Anthony I. Bernstock, Joshua D. Segar, David J. Distasio, Marcello Matulonis, Ursula Bi, Wenya Linda Front Surg Surgery Background: Metastatic brain tumors typically arise from primary malignancies of the lung, kidney, breast, skin, and colorectum. Brain metastases originating from malignancies of the female genital tract are extremely rare. We present a case of fallopian tube brain metastasis and in so doing review the pertinent literature. Case Description: We describe a 59-year-old patient with a history of fallopian tube carcinoma who presented with an incidentally identified left frontal brain mass. MRI demonstrated an enhancing lesion in the left centrum semiovale with a second enhancing lesion noted in the cerebellar vermis. She underwent a left parietal craniotomy for resection of the dominant and clinically symptomatic lesion. Immunohistochemical stains were positive for PAX8 and p53, confirming fallopian tube origin. Conclusions: Fallopian tube cancer brain metastasis is extremely uncommon. We highlight the treatment and surgical resection of this patient's BRCA1 metastatic fallopian lesion and systematically review the literature regarding the pathogenesis, diagnosis, treatment, and histologic characteristics of the previously identified fallopian tube metastases to the central nervous system. The optimal course of treatment for brain metastasis of fallopian tube carcinoma has not been clearly defined due in part to the rarity of this condition. Consistent with BRCA1 neoplasms involving the breast and ovaries, the BRCA1 status of the patient's primary tumor likely increased the risk of central nervous system dissemination. This highlights a potential benefit of early screening of individuals with metastatic gynecologic malignancies associated with BRCA1 in the absence of any neurological symptoms. Frontiers Media S.A. 2021-02-17 /pmc/articles/PMC7927667/ /pubmed/33681280 http://dx.doi.org/10.3389/fsurg.2021.594570 Text en Copyright © 2021 Jang, Bernstock, Segar, Distasio, Matulonis and Bi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Jang, Anthony I.
Bernstock, Joshua D.
Segar, David J.
Distasio, Marcello
Matulonis, Ursula
Bi, Wenya Linda
Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma
title Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma
title_full Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma
title_fullStr Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma
title_full_unstemmed Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma
title_short Case Report: Frontoparietal Metastasis From a Primary Fallopian Tube Carcinoma
title_sort case report: frontoparietal metastasis from a primary fallopian tube carcinoma
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927667/
https://www.ncbi.nlm.nih.gov/pubmed/33681280
http://dx.doi.org/10.3389/fsurg.2021.594570
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