Complement C4A Regulates Autoreactive B Cells in Murine Lupus

Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact. Despite being 99% homologous, genetic studies identified C4A as more protective than...

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Detalles Bibliográficos
Autores principales: Simoni, Léa, Presumey, Jessy, van der Poel, Cees E., Castrillon, Carlos, Chang, Sarah E., Utz, Paul J., Carroll, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927756/
https://www.ncbi.nlm.nih.gov/pubmed/33147456
http://dx.doi.org/10.1016/j.celrep.2020.108330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927756/
https://www.ncbi.nlm.nih.gov/pubmed/33147456
http://dx.doi.org/10.1016/j.celrep.2020.108330

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