Small-Molecule Antibiotics Inhibiting tRNA-Regulated Gene Expression Is a Viable Strategy for Targeting Gram-Positive Bacteria

Bacterial infections and the rise of antibiotic resistance, especially multidrug resistance, have generated a clear need for discovery of novel therapeutics. We demonstrated that a small-molecule drug, PKZ18, targets the T-box mechanism and inhibits bacterial growth. The T-box is a structurally cons...

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Detalles Bibliográficos
Autores principales: Väre, Ville Y. P., Schneider, Ryan F., Kim, Haein, Lasek-Nesselquist, Erica, McDonough, Kathleen A., Agris, Paul F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927825/
https://www.ncbi.nlm.nih.gov/pubmed/33077662
http://dx.doi.org/10.1128/AAC.01247-20

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