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Repurposing Nucleoside Analogs for Human Coronaviruses
Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed certain nucleoside analogs to be active against CoV-2 and thus needed confirmation. Here, we evaluated a panel of compounds and identified no...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927863/ https://www.ncbi.nlm.nih.gov/pubmed/33122172 http://dx.doi.org/10.1128/AAC.01652-20 |
| _version_ | 1783659756489015296 |
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| author | Zandi, Keivan Amblard, Franck Musall, Katie Downs-Bowen, Jessica Kleinbard, Ruby Oo, Adrian Cao, Dongdong Liang, Bo Russell, Olivia O. McBrayer, Tamara Bassit, Leda Kim, Baek Schinazi, Raymond F. |
| author_facet | Zandi, Keivan Amblard, Franck Musall, Katie Downs-Bowen, Jessica Kleinbard, Ruby Oo, Adrian Cao, Dongdong Liang, Bo Russell, Olivia O. McBrayer, Tamara Bassit, Leda Kim, Baek Schinazi, Raymond F. |
| author_sort | Zandi, Keivan |
| collection | PubMed |
| description | Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed certain nucleoside analogs to be active against CoV-2 and thus needed confirmation. Here, we evaluated a panel of compounds and identified novel nucleoside analogs with antiviral activity against CoV-2 and HCoV-OC43 while ruling out others. Of significance, sofosbuvir demonstrated no antiviral effect against CoV-2, and its triphosphate did not inhibit CoV-2 RNA polymerase. |
| format | Online Article Text |
| id | pubmed-7927863 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Society for Microbiology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79278632021-03-10 Repurposing Nucleoside Analogs for Human Coronaviruses Zandi, Keivan Amblard, Franck Musall, Katie Downs-Bowen, Jessica Kleinbard, Ruby Oo, Adrian Cao, Dongdong Liang, Bo Russell, Olivia O. McBrayer, Tamara Bassit, Leda Kim, Baek Schinazi, Raymond F. Antimicrob Agents Chemother Antiviral Agents Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or CoV-2). Some reports claimed certain nucleoside analogs to be active against CoV-2 and thus needed confirmation. Here, we evaluated a panel of compounds and identified novel nucleoside analogs with antiviral activity against CoV-2 and HCoV-OC43 while ruling out others. Of significance, sofosbuvir demonstrated no antiviral effect against CoV-2, and its triphosphate did not inhibit CoV-2 RNA polymerase. American Society for Microbiology 2020-12-16 /pmc/articles/PMC7927863/ /pubmed/33122172 http://dx.doi.org/10.1128/AAC.01652-20 Text en Copyright © 2020 American Society for Microbiology. https://doi.org/10.1128/ASMCopyrightv2All Rights Reserved (https://doi.org/10.1128/ASMCopyrightv2) . |
| spellingShingle | Antiviral Agents Zandi, Keivan Amblard, Franck Musall, Katie Downs-Bowen, Jessica Kleinbard, Ruby Oo, Adrian Cao, Dongdong Liang, Bo Russell, Olivia O. McBrayer, Tamara Bassit, Leda Kim, Baek Schinazi, Raymond F. Repurposing Nucleoside Analogs for Human Coronaviruses |
| title | Repurposing Nucleoside Analogs for Human Coronaviruses |
| title_full | Repurposing Nucleoside Analogs for Human Coronaviruses |
| title_fullStr | Repurposing Nucleoside Analogs for Human Coronaviruses |
| title_full_unstemmed | Repurposing Nucleoside Analogs for Human Coronaviruses |
| title_short | Repurposing Nucleoside Analogs for Human Coronaviruses |
| title_sort | repurposing nucleoside analogs for human coronaviruses |
| topic | Antiviral Agents |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927863/ https://www.ncbi.nlm.nih.gov/pubmed/33122172 http://dx.doi.org/10.1128/AAC.01652-20 |
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