The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma

The immunoglobulin (Ig) heavy and light chain variable gene mutational pattern of the B-cell receptor (BCR) in primary central nervous system lymphoma (PCNSL) cells suggests antigenic selection to drive pathogenesis and confinement to the central nervous system (CNS). This hypothesis is supported by...

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Detalles Bibliográficos
Autores principales: Montesinos-Rongen, Manuel, Terrao, Monica, May, Caroline, Marcus, Katrin, Blümcke, Ingmar, Hellmich, Martin, Küppers, Ralf, Brunn, Anna, Deckert, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927892/
https://www.ncbi.nlm.nih.gov/pubmed/32193251
http://dx.doi.org/10.3324/haematol.2019.242701

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