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Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Tau is a major driver of neurodegeneration and is implicated in over 20 diseases. Tauopathies are characterized by synaptic loss and neuroinflammation, but it is unclear if these pathological events are causally linked. Tau binds to Synaptogyrin-3 on synaptic vesicles. Here, we interfered with this...

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Detalles Bibliográficos
Autores principales:	Largo-Barrientos, Pablo, Apóstolo, Nuno, Creemers, Eline, Callaerts-Vegh, Zsuzsanna, Swerts, Jef, Davies, Caitlin, McInnes, Joseph, Wierda, Keimpe, De Strooper, Bart, Spires-Jones, Tara, de Wit, Joris, Uytterhoeven, Valerie, Verstreken, Patrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927913/ https://www.ncbi.nlm.nih.gov/pubmed/33472038 http://dx.doi.org/10.1016/j.neuron.2020.12.016

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