A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques

The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small an...

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Detalles Bibliográficos
Autores principales: Li, Yuzhong, Bi, Yanwei, Xiao, Hongjian, Yao, Yueting, Liu, Xiaojuan, Hu, Zhengrong, Duan, Jinmei, Yang, Yaoyun, Li, Zhihua, Li, Yadong, Zhang, Heng, Ding, Chen, Yang, Jianbo, Li, Haiwei, He, Zhanlong, Liu, Longding, Hu, Guangnan, Liu, Shuying, Che, Yanchun, Wang, Shixia, Li, Qihan, Lu, Shan, Cun, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Coronaviruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928010/
https://www.ncbi.nlm.nih.gov/pubmed/33555988
http://dx.doi.org/10.1080/22221751.2021.1887767
Descripción
Sumario:The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal models. More significantly, the co-delivery of DNA and protein components at the same time elicited full protection against intratracheal challenge of SARS-CoV-2 viruses in immunized rhesus macaques. As both DNA and protein vaccines have been proven safe in previous human studies, and DNA vaccines are capable of eliciting germinal center B cell development, which is critical for high-affinity memory B cell responses, the DNA and protein co-delivery vaccine approach has great potential to serve as a safe and effective approach to develop COVID-19 vaccines that provide long-term protection.

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