Cargando…
A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques
The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small an...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928010/ https://www.ncbi.nlm.nih.gov/pubmed/33555988 http://dx.doi.org/10.1080/22221751.2021.1887767 |
_version_ | 1783659776019791872 |
---|---|
author | Li, Yuzhong Bi, Yanwei Xiao, Hongjian Yao, Yueting Liu, Xiaojuan Hu, Zhengrong Duan, Jinmei Yang, Yaoyun Li, Zhihua Li, Yadong Zhang, Heng Ding, Chen Yang, Jianbo Li, Haiwei He, Zhanlong Liu, Longding Hu, Guangnan Liu, Shuying Che, Yanchun Wang, Shixia Li, Qihan Lu, Shan Cun, Wei |
author_facet | Li, Yuzhong Bi, Yanwei Xiao, Hongjian Yao, Yueting Liu, Xiaojuan Hu, Zhengrong Duan, Jinmei Yang, Yaoyun Li, Zhihua Li, Yadong Zhang, Heng Ding, Chen Yang, Jianbo Li, Haiwei He, Zhanlong Liu, Longding Hu, Guangnan Liu, Shuying Che, Yanchun Wang, Shixia Li, Qihan Lu, Shan Cun, Wei |
author_sort | Li, Yuzhong |
collection | PubMed |
description | The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal models. More significantly, the co-delivery of DNA and protein components at the same time elicited full protection against intratracheal challenge of SARS-CoV-2 viruses in immunized rhesus macaques. As both DNA and protein vaccines have been proven safe in previous human studies, and DNA vaccines are capable of eliciting germinal center B cell development, which is critical for high-affinity memory B cell responses, the DNA and protein co-delivery vaccine approach has great potential to serve as a safe and effective approach to develop COVID-19 vaccines that provide long-term protection. |
format | Online Article Text |
id | pubmed-7928010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-79280102021-03-05 A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques Li, Yuzhong Bi, Yanwei Xiao, Hongjian Yao, Yueting Liu, Xiaojuan Hu, Zhengrong Duan, Jinmei Yang, Yaoyun Li, Zhihua Li, Yadong Zhang, Heng Ding, Chen Yang, Jianbo Li, Haiwei He, Zhanlong Liu, Longding Hu, Guangnan Liu, Shuying Che, Yanchun Wang, Shixia Li, Qihan Lu, Shan Cun, Wei Emerg Microbes Infect Coronaviruses The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal models. More significantly, the co-delivery of DNA and protein components at the same time elicited full protection against intratracheal challenge of SARS-CoV-2 viruses in immunized rhesus macaques. As both DNA and protein vaccines have been proven safe in previous human studies, and DNA vaccines are capable of eliciting germinal center B cell development, which is critical for high-affinity memory B cell responses, the DNA and protein co-delivery vaccine approach has great potential to serve as a safe and effective approach to develop COVID-19 vaccines that provide long-term protection. Taylor & Francis 2021-03-01 /pmc/articles/PMC7928010/ /pubmed/33555988 http://dx.doi.org/10.1080/22221751.2021.1887767 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Coronaviruses Li, Yuzhong Bi, Yanwei Xiao, Hongjian Yao, Yueting Liu, Xiaojuan Hu, Zhengrong Duan, Jinmei Yang, Yaoyun Li, Zhihua Li, Yadong Zhang, Heng Ding, Chen Yang, Jianbo Li, Haiwei He, Zhanlong Liu, Longding Hu, Guangnan Liu, Shuying Che, Yanchun Wang, Shixia Li, Qihan Lu, Shan Cun, Wei A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques |
title | A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques |
title_full | A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques |
title_fullStr | A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques |
title_full_unstemmed | A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques |
title_short | A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques |
title_sort | novel dna and protein combination covid-19 vaccine formulation provides full protection against sars-cov-2 in rhesus macaques |
topic | Coronaviruses |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928010/ https://www.ncbi.nlm.nih.gov/pubmed/33555988 http://dx.doi.org/10.1080/22221751.2021.1887767 |
work_keys_str_mv | AT liyuzhong anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT biyanwei anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT xiaohongjian anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT yaoyueting anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liuxiaojuan anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT huzhengrong anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT duanjinmei anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT yangyaoyun anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT lizhihua anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liyadong anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT zhangheng anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT dingchen anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT yangjianbo anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT lihaiwei anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT hezhanlong anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liulongding anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT huguangnan anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liushuying anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT cheyanchun anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT wangshixia anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liqihan anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT lushan anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT cunwei anoveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liyuzhong noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT biyanwei noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT xiaohongjian noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT yaoyueting noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liuxiaojuan noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT huzhengrong noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT duanjinmei noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT yangyaoyun noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT lizhihua noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liyadong noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT zhangheng noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT dingchen noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT yangjianbo noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT lihaiwei noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT hezhanlong noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liulongding noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT huguangnan noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liushuying noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT cheyanchun noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT wangshixia noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT liqihan noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT lushan noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques AT cunwei noveldnaandproteincombinationcovid19vaccineformulationprovidesfullprotectionagainstsarscov2inrhesusmacaques |