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Genome editing of donor-derived T cells to generate allogeneic chimeric antigen receptor-modified T cells: optimizing αβ T-cell-depleted haploidentical hematopoietic stem cell transplantation

Allogeneic hematopoietic stem cell transplantation is an effective therapy for high-risk leukemias. In children, graft manipulation based on the selective removal of αβT cells and B cells has been shown to reduce the risk of acute and chronic graft-versus-host disease, thus allowing the use of haplo...

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Detalles Bibliográficos
Autores principales:	Wiebking, Volker, Lee, Ciaran M., Mostrel, Nathalie, Lahiri, Premanjali, Bak, Rasmus, Bao, Gang, Roncarolo, Maria Grazia, Bertaina, Alice, Porteus, Matthew H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928014/ https://www.ncbi.nlm.nih.gov/pubmed/32241852 http://dx.doi.org/10.3324/haematol.2019.233882

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