Cargando…

Links between gut microbiome composition and fatty liver disease in a large population sample

Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 y, but this association remains mostly unstudied in the general population because of underdiagnosis and small sample sizes. To address this knowledge gap, we stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruuskanen, Matti O., Åberg, Fredrik, Männistö, Ville, Havulinna, Aki S., Méric, Guillaume, Liu, Yang, Loomba, Rohit, Vázquez-Baeza, Yoshiki, Tripathi, Anupriya, Valsta, Liisa M., Inouye, Michael, Jousilahti, Pekka, Salomaa, Veikko, Jain, Mohit, Knight, Rob, Lahti, Leo, Niiranen, Teemu J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928040/
https://www.ncbi.nlm.nih.gov/pubmed/33651661
http://dx.doi.org/10.1080/19490976.2021.1888673
_version_ 1783659781197660160
author Ruuskanen, Matti O.
Åberg, Fredrik
Männistö, Ville
Havulinna, Aki S.
Méric, Guillaume
Liu, Yang
Loomba, Rohit
Vázquez-Baeza, Yoshiki
Tripathi, Anupriya
Valsta, Liisa M.
Inouye, Michael
Jousilahti, Pekka
Salomaa, Veikko
Jain, Mohit
Knight, Rob
Lahti, Leo
Niiranen, Teemu J.
author_facet Ruuskanen, Matti O.
Åberg, Fredrik
Männistö, Ville
Havulinna, Aki S.
Méric, Guillaume
Liu, Yang
Loomba, Rohit
Vázquez-Baeza, Yoshiki
Tripathi, Anupriya
Valsta, Liisa M.
Inouye, Michael
Jousilahti, Pekka
Salomaa, Veikko
Jain, Mohit
Knight, Rob
Lahti, Leo
Niiranen, Teemu J.
author_sort Ruuskanen, Matti O.
collection PubMed
description Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 y, but this association remains mostly unstudied in the general population because of underdiagnosis and small sample sizes. To address this knowledge gap, we studied the link between the Fatty Liver Index (FLI), a well-established proxy for fatty liver disease, and gut microbiome composition in a representative, ethnically homogeneous population sample of 6,269 Finnish participants. We based our models on biometric covariates and gut microbiome compositions from shallow metagenome sequencing. Our classification models could discriminate between individuals with a high FLI (≥60, indicates likely liver steatosis) and low FLI (<60) in internal cross-region validation, consisting of 30% of the data not used in model training, with an average AUC of 0.75 and AUPRC of 0.56 (baseline at 0.30). In addition to age and sex, our models included differences in 11 microbial groups from class Clostridia, mostly belonging to orders Lachnospirales and Oscillospirales. Our models were also predictive of the high FLI group in a different Finnish cohort, consisting of 258 participants, with an average AUC of 0.77 and AUPRC of 0.51 (baseline at 0.21). Pathway analysis of representative genomes of the positively FLI-associated taxa in (NCBI) Clostridium subclusters IV and XIVa indicated the presence of, e.g., ethanol fermentation pathways. These results support several findings from smaller case–control studies, such as the role of endogenous ethanol producers in the development of the fatty liver.
format Online
Article
Text
id pubmed-7928040
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-79280402021-03-05 Links between gut microbiome composition and fatty liver disease in a large population sample Ruuskanen, Matti O. Åberg, Fredrik Männistö, Ville Havulinna, Aki S. Méric, Guillaume Liu, Yang Loomba, Rohit Vázquez-Baeza, Yoshiki Tripathi, Anupriya Valsta, Liisa M. Inouye, Michael Jousilahti, Pekka Salomaa, Veikko Jain, Mohit Knight, Rob Lahti, Leo Niiranen, Teemu J. Gut Microbes Research Paper Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 y, but this association remains mostly unstudied in the general population because of underdiagnosis and small sample sizes. To address this knowledge gap, we studied the link between the Fatty Liver Index (FLI), a well-established proxy for fatty liver disease, and gut microbiome composition in a representative, ethnically homogeneous population sample of 6,269 Finnish participants. We based our models on biometric covariates and gut microbiome compositions from shallow metagenome sequencing. Our classification models could discriminate between individuals with a high FLI (≥60, indicates likely liver steatosis) and low FLI (<60) in internal cross-region validation, consisting of 30% of the data not used in model training, with an average AUC of 0.75 and AUPRC of 0.56 (baseline at 0.30). In addition to age and sex, our models included differences in 11 microbial groups from class Clostridia, mostly belonging to orders Lachnospirales and Oscillospirales. Our models were also predictive of the high FLI group in a different Finnish cohort, consisting of 258 participants, with an average AUC of 0.77 and AUPRC of 0.51 (baseline at 0.21). Pathway analysis of representative genomes of the positively FLI-associated taxa in (NCBI) Clostridium subclusters IV and XIVa indicated the presence of, e.g., ethanol fermentation pathways. These results support several findings from smaller case–control studies, such as the role of endogenous ethanol producers in the development of the fatty liver. Taylor & Francis 2021-03-02 /pmc/articles/PMC7928040/ /pubmed/33651661 http://dx.doi.org/10.1080/19490976.2021.1888673 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Ruuskanen, Matti O.
Åberg, Fredrik
Männistö, Ville
Havulinna, Aki S.
Méric, Guillaume
Liu, Yang
Loomba, Rohit
Vázquez-Baeza, Yoshiki
Tripathi, Anupriya
Valsta, Liisa M.
Inouye, Michael
Jousilahti, Pekka
Salomaa, Veikko
Jain, Mohit
Knight, Rob
Lahti, Leo
Niiranen, Teemu J.
Links between gut microbiome composition and fatty liver disease in a large population sample
title Links between gut microbiome composition and fatty liver disease in a large population sample
title_full Links between gut microbiome composition and fatty liver disease in a large population sample
title_fullStr Links between gut microbiome composition and fatty liver disease in a large population sample
title_full_unstemmed Links between gut microbiome composition and fatty liver disease in a large population sample
title_short Links between gut microbiome composition and fatty liver disease in a large population sample
title_sort links between gut microbiome composition and fatty liver disease in a large population sample
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928040/
https://www.ncbi.nlm.nih.gov/pubmed/33651661
http://dx.doi.org/10.1080/19490976.2021.1888673
work_keys_str_mv AT ruuskanenmattio linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT abergfredrik linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT mannistoville linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT havulinnaakis linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT mericguillaume linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT liuyang linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT loombarohit linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT vazquezbaezayoshiki linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT tripathianupriya linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT valstaliisam linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT inouyemichael linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT jousilahtipekka linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT salomaaveikko linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT jainmohit linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT knightrob linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT lahtileo linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample
AT niiranenteemuj linksbetweengutmicrobiomecompositionandfattyliverdiseaseinalargepopulationsample