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Links between gut microbiome composition and fatty liver disease in a large population sample
Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 y, but this association remains mostly unstudied in the general population because of underdiagnosis and small sample sizes. To address this knowledge gap, we stud...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928040/ https://www.ncbi.nlm.nih.gov/pubmed/33651661 http://dx.doi.org/10.1080/19490976.2021.1888673 |
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author | Ruuskanen, Matti O. Åberg, Fredrik Männistö, Ville Havulinna, Aki S. Méric, Guillaume Liu, Yang Loomba, Rohit Vázquez-Baeza, Yoshiki Tripathi, Anupriya Valsta, Liisa M. Inouye, Michael Jousilahti, Pekka Salomaa, Veikko Jain, Mohit Knight, Rob Lahti, Leo Niiranen, Teemu J. |
author_facet | Ruuskanen, Matti O. Åberg, Fredrik Männistö, Ville Havulinna, Aki S. Méric, Guillaume Liu, Yang Loomba, Rohit Vázquez-Baeza, Yoshiki Tripathi, Anupriya Valsta, Liisa M. Inouye, Michael Jousilahti, Pekka Salomaa, Veikko Jain, Mohit Knight, Rob Lahti, Leo Niiranen, Teemu J. |
author_sort | Ruuskanen, Matti O. |
collection | PubMed |
description | Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 y, but this association remains mostly unstudied in the general population because of underdiagnosis and small sample sizes. To address this knowledge gap, we studied the link between the Fatty Liver Index (FLI), a well-established proxy for fatty liver disease, and gut microbiome composition in a representative, ethnically homogeneous population sample of 6,269 Finnish participants. We based our models on biometric covariates and gut microbiome compositions from shallow metagenome sequencing. Our classification models could discriminate between individuals with a high FLI (≥60, indicates likely liver steatosis) and low FLI (<60) in internal cross-region validation, consisting of 30% of the data not used in model training, with an average AUC of 0.75 and AUPRC of 0.56 (baseline at 0.30). In addition to age and sex, our models included differences in 11 microbial groups from class Clostridia, mostly belonging to orders Lachnospirales and Oscillospirales. Our models were also predictive of the high FLI group in a different Finnish cohort, consisting of 258 participants, with an average AUC of 0.77 and AUPRC of 0.51 (baseline at 0.21). Pathway analysis of representative genomes of the positively FLI-associated taxa in (NCBI) Clostridium subclusters IV and XIVa indicated the presence of, e.g., ethanol fermentation pathways. These results support several findings from smaller case–control studies, such as the role of endogenous ethanol producers in the development of the fatty liver. |
format | Online Article Text |
id | pubmed-7928040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-79280402021-03-05 Links between gut microbiome composition and fatty liver disease in a large population sample Ruuskanen, Matti O. Åberg, Fredrik Männistö, Ville Havulinna, Aki S. Méric, Guillaume Liu, Yang Loomba, Rohit Vázquez-Baeza, Yoshiki Tripathi, Anupriya Valsta, Liisa M. Inouye, Michael Jousilahti, Pekka Salomaa, Veikko Jain, Mohit Knight, Rob Lahti, Leo Niiranen, Teemu J. Gut Microbes Research Paper Fatty liver disease is the most common liver disease in the world. Its connection with the gut microbiome has been known for at least 80 y, but this association remains mostly unstudied in the general population because of underdiagnosis and small sample sizes. To address this knowledge gap, we studied the link between the Fatty Liver Index (FLI), a well-established proxy for fatty liver disease, and gut microbiome composition in a representative, ethnically homogeneous population sample of 6,269 Finnish participants. We based our models on biometric covariates and gut microbiome compositions from shallow metagenome sequencing. Our classification models could discriminate between individuals with a high FLI (≥60, indicates likely liver steatosis) and low FLI (<60) in internal cross-region validation, consisting of 30% of the data not used in model training, with an average AUC of 0.75 and AUPRC of 0.56 (baseline at 0.30). In addition to age and sex, our models included differences in 11 microbial groups from class Clostridia, mostly belonging to orders Lachnospirales and Oscillospirales. Our models were also predictive of the high FLI group in a different Finnish cohort, consisting of 258 participants, with an average AUC of 0.77 and AUPRC of 0.51 (baseline at 0.21). Pathway analysis of representative genomes of the positively FLI-associated taxa in (NCBI) Clostridium subclusters IV and XIVa indicated the presence of, e.g., ethanol fermentation pathways. These results support several findings from smaller case–control studies, such as the role of endogenous ethanol producers in the development of the fatty liver. Taylor & Francis 2021-03-02 /pmc/articles/PMC7928040/ /pubmed/33651661 http://dx.doi.org/10.1080/19490976.2021.1888673 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Ruuskanen, Matti O. Åberg, Fredrik Männistö, Ville Havulinna, Aki S. Méric, Guillaume Liu, Yang Loomba, Rohit Vázquez-Baeza, Yoshiki Tripathi, Anupriya Valsta, Liisa M. Inouye, Michael Jousilahti, Pekka Salomaa, Veikko Jain, Mohit Knight, Rob Lahti, Leo Niiranen, Teemu J. Links between gut microbiome composition and fatty liver disease in a large population sample |
title | Links between gut microbiome composition and fatty liver disease in a large population sample |
title_full | Links between gut microbiome composition and fatty liver disease in a large population sample |
title_fullStr | Links between gut microbiome composition and fatty liver disease in a large population sample |
title_full_unstemmed | Links between gut microbiome composition and fatty liver disease in a large population sample |
title_short | Links between gut microbiome composition and fatty liver disease in a large population sample |
title_sort | links between gut microbiome composition and fatty liver disease in a large population sample |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928040/ https://www.ncbi.nlm.nih.gov/pubmed/33651661 http://dx.doi.org/10.1080/19490976.2021.1888673 |
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