Effects of non-vascularized adipose tissue transplantation on its genetic profile

Subcutaneous adipose tissue (SAT) is recognized as a highly active metabolic and inflammatory tissue. Interestingly, adipose tissue transplantation is widely performed in plastic surgery via lipofilling, yet little is known about the gene alteration of adipocytes after transplantation. We performed...

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Detalles Bibliográficos
Autores principales: Schreiter, Jeannine S., Kurow, L. O, Langer, S, Steinert, M, Massier, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928050/
https://www.ncbi.nlm.nih.gov/pubmed/33648423
http://dx.doi.org/10.1080/21623945.2021.1889815
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author Schreiter, Jeannine S.
Kurow, L. O
Langer, S
Steinert, M
Massier, L
author_facet Schreiter, Jeannine S.
Kurow, L. O
Langer, S
Steinert, M
Massier, L
author_sort Schreiter, Jeannine S.
collection PubMed
description Subcutaneous adipose tissue (SAT) is recognized as a highly active metabolic and inflammatory tissue. Interestingly, adipose tissue transplantation is widely performed in plastic surgery via lipofilling, yet little is known about the gene alteration of adipocytes after transplantation. We performed an RNA-expression analysis of fat transplants before and after fat transplantation. In C57BL/6 N mice SAT was autologously transplanted. Samples of SAT were analysed before transplantation, 7, and 15 days after transplantation and gene expression profiles were measured. Analysis revealed that lipid metabolism-related genes were downregulated while inflammatory and extracellular matrix related genes were up-regulated 7 and 15 days after transplantation. When comparing gene expression profile 7 days after transplantation to 15 days after transplantation developmental pathways showed most changes.
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spelling pubmed-79280502021-03-05 Effects of non-vascularized adipose tissue transplantation on its genetic profile Schreiter, Jeannine S. Kurow, L. O Langer, S Steinert, M Massier, L Adipocyte Brief Report Subcutaneous adipose tissue (SAT) is recognized as a highly active metabolic and inflammatory tissue. Interestingly, adipose tissue transplantation is widely performed in plastic surgery via lipofilling, yet little is known about the gene alteration of adipocytes after transplantation. We performed an RNA-expression analysis of fat transplants before and after fat transplantation. In C57BL/6 N mice SAT was autologously transplanted. Samples of SAT were analysed before transplantation, 7, and 15 days after transplantation and gene expression profiles were measured. Analysis revealed that lipid metabolism-related genes were downregulated while inflammatory and extracellular matrix related genes were up-regulated 7 and 15 days after transplantation. When comparing gene expression profile 7 days after transplantation to 15 days after transplantation developmental pathways showed most changes. Taylor & Francis 2021-03-01 /pmc/articles/PMC7928050/ /pubmed/33648423 http://dx.doi.org/10.1080/21623945.2021.1889815 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Schreiter, Jeannine S.
Kurow, L. O
Langer, S
Steinert, M
Massier, L
Effects of non-vascularized adipose tissue transplantation on its genetic profile
title Effects of non-vascularized adipose tissue transplantation on its genetic profile
title_full Effects of non-vascularized adipose tissue transplantation on its genetic profile
title_fullStr Effects of non-vascularized adipose tissue transplantation on its genetic profile
title_full_unstemmed Effects of non-vascularized adipose tissue transplantation on its genetic profile
title_short Effects of non-vascularized adipose tissue transplantation on its genetic profile
title_sort effects of non-vascularized adipose tissue transplantation on its genetic profile
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928050/
https://www.ncbi.nlm.nih.gov/pubmed/33648423
http://dx.doi.org/10.1080/21623945.2021.1889815
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