Controversies around the function of LARP1

The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it....

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Detalles Bibliográficos
Autores principales: Berman, Andrea J., Thoreen, Carson C., Dedeic, Zinaida, Chettle, James, Roux, Philippe P., Blagden, Sarah P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928164/
https://www.ncbi.nlm.nih.gov/pubmed/32233986
http://dx.doi.org/10.1080/15476286.2020.1733787
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author Berman, Andrea J.
Thoreen, Carson C.
Dedeic, Zinaida
Chettle, James
Roux, Philippe P.
Blagden, Sarah P.
author_facet Berman, Andrea J.
Thoreen, Carson C.
Dedeic, Zinaida
Chettle, James
Roux, Philippe P.
Blagden, Sarah P.
author_sort Berman, Andrea J.
collection PubMed
description The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scientists in the field to discuss these and other contradictory findings.
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spelling pubmed-79281642021-03-11 Controversies around the function of LARP1 Berman, Andrea J. Thoreen, Carson C. Dedeic, Zinaida Chettle, James Roux, Philippe P. Blagden, Sarah P. RNA Biol Review The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scientists in the field to discuss these and other contradictory findings. Taylor & Francis 2020-04-01 /pmc/articles/PMC7928164/ /pubmed/32233986 http://dx.doi.org/10.1080/15476286.2020.1733787 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Berman, Andrea J.
Thoreen, Carson C.
Dedeic, Zinaida
Chettle, James
Roux, Philippe P.
Blagden, Sarah P.
Controversies around the function of LARP1
title Controversies around the function of LARP1
title_full Controversies around the function of LARP1
title_fullStr Controversies around the function of LARP1
title_full_unstemmed Controversies around the function of LARP1
title_short Controversies around the function of LARP1
title_sort controversies around the function of larp1
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928164/
https://www.ncbi.nlm.nih.gov/pubmed/32233986
http://dx.doi.org/10.1080/15476286.2020.1733787
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