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Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
BACKGROUND: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928197/ https://www.ncbi.nlm.nih.gov/pubmed/33658032 http://dx.doi.org/10.1186/s12931-021-01666-3 |
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author | Ricci, Alberto Pagliuca, Alessandra D’Ascanio, Michela Innammorato, Marta De Vitis, Claudia Mancini, Rita Giovagnoli, Simonetta Facchiano, Francesco Sposato, Bruno Anibaldi, Paolo Marcolongo, Adriano De Dominicis, Chiara Laghi, Andrea Muscogiuri, Emanuele Sciacchitano, Salvatore |
author_facet | Ricci, Alberto Pagliuca, Alessandra D’Ascanio, Michela Innammorato, Marta De Vitis, Claudia Mancini, Rita Giovagnoli, Simonetta Facchiano, Francesco Sposato, Bruno Anibaldi, Paolo Marcolongo, Adriano De Dominicis, Chiara Laghi, Andrea Muscogiuri, Emanuele Sciacchitano, Salvatore |
author_sort | Ricci, Alberto |
collection | PubMed |
description | BACKGROUND: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with altered immune responses and infections. In the present study, we evaluated Vitamin D plasma levels in patients affected with different lung involvement during COVID-19 infection. METHODS: Lymphocyte phenotypes were assessed by flow cytometry. Thoracic CT scan involvement was obtained by an image analysis program. RESULTS: Vitamin D levels were deficient in (80%) of patients, insufficient in (6.5%) and normal in (13.5%). Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement. CONCLUSIONS: Vitamin D deficiency is associated with compromised inflammatory responses and higher pulmonary involvement in COVID-19 affected patients. Vitamin D assessment, during COVID-19 infection, could be a useful analysis for possible therapeutic interventions. Trial registration: 'retrospectively registered'. |
format | Online Article Text |
id | pubmed-7928197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-79281972021-03-04 Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients Ricci, Alberto Pagliuca, Alessandra D’Ascanio, Michela Innammorato, Marta De Vitis, Claudia Mancini, Rita Giovagnoli, Simonetta Facchiano, Francesco Sposato, Bruno Anibaldi, Paolo Marcolongo, Adriano De Dominicis, Chiara Laghi, Andrea Muscogiuri, Emanuele Sciacchitano, Salvatore Respir Res Research BACKGROUND: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with altered immune responses and infections. In the present study, we evaluated Vitamin D plasma levels in patients affected with different lung involvement during COVID-19 infection. METHODS: Lymphocyte phenotypes were assessed by flow cytometry. Thoracic CT scan involvement was obtained by an image analysis program. RESULTS: Vitamin D levels were deficient in (80%) of patients, insufficient in (6.5%) and normal in (13.5%). Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement. CONCLUSIONS: Vitamin D deficiency is associated with compromised inflammatory responses and higher pulmonary involvement in COVID-19 affected patients. Vitamin D assessment, during COVID-19 infection, could be a useful analysis for possible therapeutic interventions. Trial registration: 'retrospectively registered'. BioMed Central 2021-03-03 2021 /pmc/articles/PMC7928197/ /pubmed/33658032 http://dx.doi.org/10.1186/s12931-021-01666-3 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Ricci, Alberto Pagliuca, Alessandra D’Ascanio, Michela Innammorato, Marta De Vitis, Claudia Mancini, Rita Giovagnoli, Simonetta Facchiano, Francesco Sposato, Bruno Anibaldi, Paolo Marcolongo, Adriano De Dominicis, Chiara Laghi, Andrea Muscogiuri, Emanuele Sciacchitano, Salvatore Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients |
title | Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients |
title_full | Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients |
title_fullStr | Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients |
title_full_unstemmed | Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients |
title_short | Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients |
title_sort | circulating vitamin d levels status and clinical prognostic indices in covid-19 patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928197/ https://www.ncbi.nlm.nih.gov/pubmed/33658032 http://dx.doi.org/10.1186/s12931-021-01666-3 |
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