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Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients

BACKGROUND: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with...

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Autores principales: Ricci, Alberto, Pagliuca, Alessandra, D’Ascanio, Michela, Innammorato, Marta, De Vitis, Claudia, Mancini, Rita, Giovagnoli, Simonetta, Facchiano, Francesco, Sposato, Bruno, Anibaldi, Paolo, Marcolongo, Adriano, De Dominicis, Chiara, Laghi, Andrea, Muscogiuri, Emanuele, Sciacchitano, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928197/
https://www.ncbi.nlm.nih.gov/pubmed/33658032
http://dx.doi.org/10.1186/s12931-021-01666-3
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author Ricci, Alberto
Pagliuca, Alessandra
D’Ascanio, Michela
Innammorato, Marta
De Vitis, Claudia
Mancini, Rita
Giovagnoli, Simonetta
Facchiano, Francesco
Sposato, Bruno
Anibaldi, Paolo
Marcolongo, Adriano
De Dominicis, Chiara
Laghi, Andrea
Muscogiuri, Emanuele
Sciacchitano, Salvatore
author_facet Ricci, Alberto
Pagliuca, Alessandra
D’Ascanio, Michela
Innammorato, Marta
De Vitis, Claudia
Mancini, Rita
Giovagnoli, Simonetta
Facchiano, Francesco
Sposato, Bruno
Anibaldi, Paolo
Marcolongo, Adriano
De Dominicis, Chiara
Laghi, Andrea
Muscogiuri, Emanuele
Sciacchitano, Salvatore
author_sort Ricci, Alberto
collection PubMed
description BACKGROUND: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with altered immune responses and infections. In the present study, we evaluated Vitamin D plasma levels in patients affected with different lung involvement during COVID-19 infection. METHODS: Lymphocyte phenotypes were assessed by flow cytometry. Thoracic CT scan involvement was obtained by an image analysis program. RESULTS: Vitamin D levels were deficient in (80%) of patients, insufficient in (6.5%) and normal in (13.5%). Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement. CONCLUSIONS: Vitamin D deficiency is associated with compromised inflammatory responses and higher pulmonary involvement in COVID-19 affected patients. Vitamin D assessment, during COVID-19 infection, could be a useful analysis for possible therapeutic interventions. Trial registration: 'retrospectively registered'.
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spelling pubmed-79281972021-03-04 Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients Ricci, Alberto Pagliuca, Alessandra D’Ascanio, Michela Innammorato, Marta De Vitis, Claudia Mancini, Rita Giovagnoli, Simonetta Facchiano, Francesco Sposato, Bruno Anibaldi, Paolo Marcolongo, Adriano De Dominicis, Chiara Laghi, Andrea Muscogiuri, Emanuele Sciacchitano, Salvatore Respir Res Research BACKGROUND: Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T lymphocytes. Interestingly, Vitamin D deficiency has been often associated with altered immune responses and infections. In the present study, we evaluated Vitamin D plasma levels in patients affected with different lung involvement during COVID-19 infection. METHODS: Lymphocyte phenotypes were assessed by flow cytometry. Thoracic CT scan involvement was obtained by an image analysis program. RESULTS: Vitamin D levels were deficient in (80%) of patients, insufficient in (6.5%) and normal in (13.5%). Patients with very low Vitamin D plasma levels had more elevated D-Dimer values, a more elevated B lymphocyte cell count, a reduction of CD8 + T lymphocytes with a low CD4/CD8 ratio, more compromised clinical findings (measured by LIPI and SOFA scores) and thoracic CT scan involvement. CONCLUSIONS: Vitamin D deficiency is associated with compromised inflammatory responses and higher pulmonary involvement in COVID-19 affected patients. Vitamin D assessment, during COVID-19 infection, could be a useful analysis for possible therapeutic interventions. Trial registration: 'retrospectively registered'. BioMed Central 2021-03-03 2021 /pmc/articles/PMC7928197/ /pubmed/33658032 http://dx.doi.org/10.1186/s12931-021-01666-3 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ricci, Alberto
Pagliuca, Alessandra
D’Ascanio, Michela
Innammorato, Marta
De Vitis, Claudia
Mancini, Rita
Giovagnoli, Simonetta
Facchiano, Francesco
Sposato, Bruno
Anibaldi, Paolo
Marcolongo, Adriano
De Dominicis, Chiara
Laghi, Andrea
Muscogiuri, Emanuele
Sciacchitano, Salvatore
Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
title Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
title_full Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
title_fullStr Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
title_full_unstemmed Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
title_short Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
title_sort circulating vitamin d levels status and clinical prognostic indices in covid-19 patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928197/
https://www.ncbi.nlm.nih.gov/pubmed/33658032
http://dx.doi.org/10.1186/s12931-021-01666-3
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