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The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion)

Mild traumatic brain injury (mild TBI), often referred to as concussion, is the most common form of TBI and affects millions of people each year. A history of mild TBI increases the risk of developing emotional and neurocognitive disorders later in life that can impact on day to day living. These in...

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Autores principales: Verboon, Laura N., Patel, Hiren C., Greenhalgh, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928307/
https://www.ncbi.nlm.nih.gov/pubmed/33679762
http://dx.doi.org/10.3389/fimmu.2021.620698
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author Verboon, Laura N.
Patel, Hiren C.
Greenhalgh, Andrew D.
author_facet Verboon, Laura N.
Patel, Hiren C.
Greenhalgh, Andrew D.
author_sort Verboon, Laura N.
collection PubMed
description Mild traumatic brain injury (mild TBI), often referred to as concussion, is the most common form of TBI and affects millions of people each year. A history of mild TBI increases the risk of developing emotional and neurocognitive disorders later in life that can impact on day to day living. These include anxiety and depression, as well as neurodegenerative conditions such as chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD). Actions of brain resident or peripherally recruited immune cells are proposed to be key regulators across these diseases and mood disorders. Here, we will assess the impact of mild TBI on brain and patient health, and evaluate the recent evidence for immune cell involvement in its pathogenesis.
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spelling pubmed-79283072021-03-04 The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion) Verboon, Laura N. Patel, Hiren C. Greenhalgh, Andrew D. Front Immunol Immunology Mild traumatic brain injury (mild TBI), often referred to as concussion, is the most common form of TBI and affects millions of people each year. A history of mild TBI increases the risk of developing emotional and neurocognitive disorders later in life that can impact on day to day living. These include anxiety and depression, as well as neurodegenerative conditions such as chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD). Actions of brain resident or peripherally recruited immune cells are proposed to be key regulators across these diseases and mood disorders. Here, we will assess the impact of mild TBI on brain and patient health, and evaluate the recent evidence for immune cell involvement in its pathogenesis. Frontiers Media S.A. 2021-02-15 /pmc/articles/PMC7928307/ /pubmed/33679762 http://dx.doi.org/10.3389/fimmu.2021.620698 Text en Copyright © 2021 Verboon, Patel and Greenhalgh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Verboon, Laura N.
Patel, Hiren C.
Greenhalgh, Andrew D.
The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion)
title The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion)
title_full The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion)
title_fullStr The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion)
title_full_unstemmed The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion)
title_short The Immune System's Role in the Consequences of Mild Traumatic Brain Injury (Concussion)
title_sort immune system's role in the consequences of mild traumatic brain injury (concussion)
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928307/
https://www.ncbi.nlm.nih.gov/pubmed/33679762
http://dx.doi.org/10.3389/fimmu.2021.620698
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