Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties

Cathepsin D (CTSD) is a lysosomal protease important for the degradation of various substrates, including disease-associated proteins like α-synuclein (a-syn), amyloid precursor protein (APP) and tau, all of which tend to aggregate if not efficiently degraded. Hence, it is not surprising that geneti...

Descripción completa

Detalles Bibliográficos
Autores principales: Bunk, Josina, Prieto Huarcaya, Susy, Drobny, Alice, Dobert, Jan Philipp, Walther, Lina, Rose-John, Stefan, Arnold, Philipp, Zunke, Friederike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928348/
https://www.ncbi.nlm.nih.gov/pubmed/33681191
http://dx.doi.org/10.3389/fcell.2021.581805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928348/
https://www.ncbi.nlm.nih.gov/pubmed/33681191
http://dx.doi.org/10.3389/fcell.2021.581805

Ejemplares similares