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Association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years

AIM: Lower urinary tract symptoms (LUTS) result in morbidities; however, their association with the occurrence of hip fracture is relatively unknown in the context of Asian studies. The purpose of the study was to investigate this link with the hip fracture risk in Taiwanese men and women aged 50 ye...

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Autores principales: Liu, Pin-Sung, Huang, Huei-Kai, Ding, Dah-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928482/
https://www.ncbi.nlm.nih.gov/pubmed/33657118
http://dx.doi.org/10.1371/journal.pone.0246653
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author Liu, Pin-Sung
Huang, Huei-Kai
Ding, Dah-Ching
author_facet Liu, Pin-Sung
Huang, Huei-Kai
Ding, Dah-Ching
author_sort Liu, Pin-Sung
collection PubMed
description AIM: Lower urinary tract symptoms (LUTS) result in morbidities; however, their association with the occurrence of hip fracture is relatively unknown in the context of Asian studies. The purpose of the study was to investigate this link with the hip fracture risk in Taiwanese men and women aged 50 years and above. MATERIALS AND METHODS: From 2000 through 2012, a population-based retrospective cohort study was conducted; claims data of 18,976 patients diagnosed with LUTS (dysuria, urinary retention, incontinence, and increased urinary frequency and urgency) were retrieved from Taiwan’s National Health Insurance Research Database. The patients were compared with 1:2 age, sex, and index year-matched controls (comparison group, n = 37,952). The incidence and hazard ratios of the hip fracture risk were calculated by the Cox proportional hazard regression models. RESULTS: The mean age was 66.2 ± 9.7 years, and the proportion of men was 58.1% in both study groups. Fractures occurred in 772 patients and 1,156 control subjects. The corresponding incidences were 7.0 and 5.0/1000 person-years. Compared to the control subjects, the patients with LUTS had an increased hip fracture risk [adjusted hazard ratio (aHR) = 1.29; 95% confidence interval (CI): 1.17–1.42]. LUTS was independently associated with an increased hip fracture risk in both men (aHR = 1.24; 95% CI: 1.08–1.42) and women (aHR = 1.34; 95% CI: 1.18–1.53) (p for interaction = 0.557). Similarly, the subgroup effect of age on hip fracture risks was not found (p for interaction = 0.665). CONCLUSION: The study found LUTS was associated with an increased risk of hip fracture. Large-scale prospective studies in diverse populations are required to investigate causalities.
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spelling pubmed-79284822021-03-10 Association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years Liu, Pin-Sung Huang, Huei-Kai Ding, Dah-Ching PLoS One Research Article AIM: Lower urinary tract symptoms (LUTS) result in morbidities; however, their association with the occurrence of hip fracture is relatively unknown in the context of Asian studies. The purpose of the study was to investigate this link with the hip fracture risk in Taiwanese men and women aged 50 years and above. MATERIALS AND METHODS: From 2000 through 2012, a population-based retrospective cohort study was conducted; claims data of 18,976 patients diagnosed with LUTS (dysuria, urinary retention, incontinence, and increased urinary frequency and urgency) were retrieved from Taiwan’s National Health Insurance Research Database. The patients were compared with 1:2 age, sex, and index year-matched controls (comparison group, n = 37,952). The incidence and hazard ratios of the hip fracture risk were calculated by the Cox proportional hazard regression models. RESULTS: The mean age was 66.2 ± 9.7 years, and the proportion of men was 58.1% in both study groups. Fractures occurred in 772 patients and 1,156 control subjects. The corresponding incidences were 7.0 and 5.0/1000 person-years. Compared to the control subjects, the patients with LUTS had an increased hip fracture risk [adjusted hazard ratio (aHR) = 1.29; 95% confidence interval (CI): 1.17–1.42]. LUTS was independently associated with an increased hip fracture risk in both men (aHR = 1.24; 95% CI: 1.08–1.42) and women (aHR = 1.34; 95% CI: 1.18–1.53) (p for interaction = 0.557). Similarly, the subgroup effect of age on hip fracture risks was not found (p for interaction = 0.665). CONCLUSION: The study found LUTS was associated with an increased risk of hip fracture. Large-scale prospective studies in diverse populations are required to investigate causalities. Public Library of Science 2021-03-03 /pmc/articles/PMC7928482/ /pubmed/33657118 http://dx.doi.org/10.1371/journal.pone.0246653 Text en © 2021 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Liu, Pin-Sung
Huang, Huei-Kai
Ding, Dah-Ching
Association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years
title Association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years
title_full Association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years
title_fullStr Association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years
title_full_unstemmed Association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years
title_short Association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years
title_sort association of lower urinary tract symptoms and hip fracture in adults aged ≥ 50 years
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928482/
https://www.ncbi.nlm.nih.gov/pubmed/33657118
http://dx.doi.org/10.1371/journal.pone.0246653
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