Cargando…

A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

BACKGROUND AND OBJECTIVES: Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to condu...

Descripción completa

Detalles Bibliográficos
Autores principales: Amlashi, Fazel Isapanah, Norouzi, Zahra, Sohrabi, Ahmad, Shirzad-Aski, Hesamaddin, Norouzi, Alireza, Ashkbari, Ali, Gilani, Naghme, Fatemi, Seyed Alireza, Besharat, Sima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928511/
https://www.ncbi.nlm.nih.gov/pubmed/33657108
http://dx.doi.org/10.1371/journal.pone.0241156
_version_ 1783659872595738624
author Amlashi, Fazel Isapanah
Norouzi, Zahra
Sohrabi, Ahmad
Shirzad-Aski, Hesamaddin
Norouzi, Alireza
Ashkbari, Ali
Gilani, Naghme
Fatemi, Seyed Alireza
Besharat, Sima
author_facet Amlashi, Fazel Isapanah
Norouzi, Zahra
Sohrabi, Ahmad
Shirzad-Aski, Hesamaddin
Norouzi, Alireza
Ashkbari, Ali
Gilani, Naghme
Fatemi, Seyed Alireza
Besharat, Sima
author_sort Amlashi, Fazel Isapanah
collection PubMed
description BACKGROUND AND OBJECTIVES: Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization. DATA SOURCES: Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated. SYNTHESIS METHODS: Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed. RESULTS: Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45–0.70; P < 0.001), with no publication bias (P = 0.825). The L’Abbé plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity. CONCLUSIONS: According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients. SYSTEMATIC REVIEW REGISTRATION NUMBER (PROSPERO): CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=167730.
format Online
Article
Text
id pubmed-7928511
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-79285112021-03-10 A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease Amlashi, Fazel Isapanah Norouzi, Zahra Sohrabi, Ahmad Shirzad-Aski, Hesamaddin Norouzi, Alireza Ashkbari, Ali Gilani, Naghme Fatemi, Seyed Alireza Besharat, Sima PLoS One Research Article BACKGROUND AND OBJECTIVES: Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization. DATA SOURCES: Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated. SYNTHESIS METHODS: Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed. RESULTS: Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45–0.70; P < 0.001), with no publication bias (P = 0.825). The L’Abbé plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity. CONCLUSIONS: According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients. SYSTEMATIC REVIEW REGISTRATION NUMBER (PROSPERO): CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=167730. Public Library of Science 2021-03-03 /pmc/articles/PMC7928511/ /pubmed/33657108 http://dx.doi.org/10.1371/journal.pone.0241156 Text en © 2021 Amlashi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Amlashi, Fazel Isapanah
Norouzi, Zahra
Sohrabi, Ahmad
Shirzad-Aski, Hesamaddin
Norouzi, Alireza
Ashkbari, Ali
Gilani, Naghme
Fatemi, Seyed Alireza
Besharat, Sima
A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease
title A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease
title_full A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease
title_fullStr A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease
title_full_unstemmed A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease
title_short A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease
title_sort systematic review and meta-analysis for association of helicobacter pylori colonization and celiac disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928511/
https://www.ncbi.nlm.nih.gov/pubmed/33657108
http://dx.doi.org/10.1371/journal.pone.0241156
work_keys_str_mv AT amlashifazelisapanah asystematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT norouzizahra asystematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT sohrabiahmad asystematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT shirzadaskihesamaddin asystematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT norouzialireza asystematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT ashkbariali asystematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT gilaninaghme asystematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT fatemiseyedalireza asystematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT besharatsima asystematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT amlashifazelisapanah systematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT norouzizahra systematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT sohrabiahmad systematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT shirzadaskihesamaddin systematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT norouzialireza systematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT ashkbariali systematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT gilaninaghme systematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT fatemiseyedalireza systematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease
AT besharatsima systematicreviewandmetaanalysisforassociationofhelicobacterpyloricolonizationandceliacdisease