Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests

A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger prick vo...

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Detalles Bibliográficos
Autores principales: Morshed, Muhammad, Sekirov, Inna, McLennan, Meghan, Levett, Paul N, Chahil, Navdeep, Mak, Annie, Carruthers, Erin, Pidduck, Tamara, Kustra, Jesse, Laley, Jonathan, Lee, Min-Kuang, Chu, Kenneth, Burgess, Fred, Vijh, Rohit, Willis, Lori, Wada, Ray, Blancaflor, Rosemarie, Boraston, Suni, Hayden, Althea, Krajden, Mel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928643/
https://www.ncbi.nlm.nih.gov/pubmed/33723509
http://dx.doi.org/10.1093/ofid/ofab043
Descripción
Sumario:A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger prick volume variability, hemolysis, cassette readability, and operator training.

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