Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests

A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger prick vo...

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Autores principales: Morshed, Muhammad, Sekirov, Inna, McLennan, Meghan, Levett, Paul N, Chahil, Navdeep, Mak, Annie, Carruthers, Erin, Pidduck, Tamara, Kustra, Jesse, Laley, Jonathan, Lee, Min-Kuang, Chu, Kenneth, Burgess, Fred, Vijh, Rohit, Willis, Lori, Wada, Ray, Blancaflor, Rosemarie, Boraston, Suni, Hayden, Althea, Krajden, Mel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928643/
https://www.ncbi.nlm.nih.gov/pubmed/33723509
http://dx.doi.org/10.1093/ofid/ofab043
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author Morshed, Muhammad
Sekirov, Inna
McLennan, Meghan
Levett, Paul N
Chahil, Navdeep
Mak, Annie
Carruthers, Erin
Pidduck, Tamara
Kustra, Jesse
Laley, Jonathan
Lee, Min-Kuang
Chu, Kenneth
Burgess, Fred
Vijh, Rohit
Willis, Lori
Wada, Ray
Blancaflor, Rosemarie
Boraston, Suni
Hayden, Althea
Krajden, Mel
author_facet Morshed, Muhammad
Sekirov, Inna
McLennan, Meghan
Levett, Paul N
Chahil, Navdeep
Mak, Annie
Carruthers, Erin
Pidduck, Tamara
Kustra, Jesse
Laley, Jonathan
Lee, Min-Kuang
Chu, Kenneth
Burgess, Fred
Vijh, Rohit
Willis, Lori
Wada, Ray
Blancaflor, Rosemarie
Boraston, Suni
Hayden, Althea
Krajden, Mel
author_sort Morshed, Muhammad
collection PubMed
description A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger prick volume variability, hemolysis, cassette readability, and operator training.
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spelling pubmed-79286432021-03-04 Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests Morshed, Muhammad Sekirov, Inna McLennan, Meghan Levett, Paul N Chahil, Navdeep Mak, Annie Carruthers, Erin Pidduck, Tamara Kustra, Jesse Laley, Jonathan Lee, Min-Kuang Chu, Kenneth Burgess, Fred Vijh, Rohit Willis, Lori Wada, Ray Blancaflor, Rosemarie Boraston, Suni Hayden, Althea Krajden, Mel Open Forum Infect Dis Brief Reports A comparison of rapid point-of-care serology tests using finger prick and venous blood was done on 278 participants. In a laboratory setting, immunoglobulin G (IgG) sensitivity neared 100%; however, IgG sensitivity dramatically dropped (82%) in field testing. Possible factors include finger prick volume variability, hemolysis, cassette readability, and operator training. Oxford University Press 2021-01-28 /pmc/articles/PMC7928643/ /pubmed/33723509 http://dx.doi.org/10.1093/ofid/ofab043 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Morshed, Muhammad
Sekirov, Inna
McLennan, Meghan
Levett, Paul N
Chahil, Navdeep
Mak, Annie
Carruthers, Erin
Pidduck, Tamara
Kustra, Jesse
Laley, Jonathan
Lee, Min-Kuang
Chu, Kenneth
Burgess, Fred
Vijh, Rohit
Willis, Lori
Wada, Ray
Blancaflor, Rosemarie
Boraston, Suni
Hayden, Althea
Krajden, Mel
Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests
title Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests
title_full Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests
title_fullStr Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests
title_full_unstemmed Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests
title_short Comparative Analysis of Capillary vs Venous Blood for Serologic Detection of SARS-CoV-2 Antibodies by RPOC Lateral Flow Tests
title_sort comparative analysis of capillary vs venous blood for serologic detection of sars-cov-2 antibodies by rpoc lateral flow tests
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928643/
https://www.ncbi.nlm.nih.gov/pubmed/33723509
http://dx.doi.org/10.1093/ofid/ofab043
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