Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus

BACKGROUND: REGN3048 and REGN3051 are human monoclonal antibodies (mAb) targeting the spike glycoprotein on the Middle East respiratory syndrome coronavirus (MERS-CoV), which binds to the receptor dipeptidyl peptidase-4 (DPP4) and is necessary for infection of susceptible cells. METHODS: Preclinical...

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Detalles Bibliográficos
Autores principales: Sivapalasingam, Sumathi, Saviolakis, George A, Kulcsar, Kirsten, Nakamura, Aya, Conrad, Thomas, Hassanein, Mohamed, Sumner, Giane, Elango, Chinnasamy, Kamal, Mohamed A, Eng, Simon, Kyratsous, Christos A, Musser, Bret J, Frieman, Matthew, Kantrowitz, Joel, Weinreich, David M, Yancopoulos, George, Stahl, Neil, Lipsich, Leah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928873/
https://www.ncbi.nlm.nih.gov/pubmed/33507266
http://dx.doi.org/10.1093/infdis/jiab036

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