Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow

[Image: see text] The scale-up of a chiral bicyclic homopiperazine of pharmaceutical interest was investigated. The outcome and safety profile of a key batch ring-expansion step via Schmidt rearrangement was improved using continuous-flow chemistry. The selectivity of nitrogen insertion for the ring...

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Detalles Bibliográficos
Autores principales: Brown, Michael, Aljarah, Mohammed, Asiki, Hannah, Leung, Leo M. H., Smithen, Deborah A., Miller, Natalie, Nemeth, Gabor, Davies, Lawrence, Niculescu-Duvaz, Dan, Zambon, Alfonso, Springer, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928940/
https://www.ncbi.nlm.nih.gov/pubmed/33679122
http://dx.doi.org/10.1021/acs.oprd.0c00361

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