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Cytokine storms, evolution and COVID-19

Since the identification of severe illness caused by the novel coronavirus SARS-CoV-2, the role of the host immune system in causing disease has attracted widespread attention, along with intense interest in medical interventions that target the host immune response. A wide variety of agents have be...

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Detalles Bibliográficos
Autores principales: Alcock, Joe, Masters, Alix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928963/
https://www.ncbi.nlm.nih.gov/pubmed/34552755
http://dx.doi.org/10.1093/emph/eoab005
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author Alcock, Joe
Masters, Alix
author_facet Alcock, Joe
Masters, Alix
author_sort Alcock, Joe
collection PubMed
description Since the identification of severe illness caused by the novel coronavirus SARS-CoV-2, the role of the host immune system in causing disease has attracted widespread attention, along with intense interest in medical interventions that target the host immune response. A wide variety of agents have been proposed to treat a cytokine storm in coronavirus disease 2019 (COVID-19), but so far, only one class of medications, corticosteroids, has proved useful. In recent decades, experimental therapies for cytokine storms have been tried and mostly failed to help patients with severe sepsis and other infections. We summarize this history in order to frame expectations for novel interventions in COVID-19 and to bring an evolutionary medicine perspective to the concept of cytokine storms and their treatment.
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spelling pubmed-79289632021-03-04 Cytokine storms, evolution and COVID-19 Alcock, Joe Masters, Alix Evol Med Public Health Review Since the identification of severe illness caused by the novel coronavirus SARS-CoV-2, the role of the host immune system in causing disease has attracted widespread attention, along with intense interest in medical interventions that target the host immune response. A wide variety of agents have been proposed to treat a cytokine storm in coronavirus disease 2019 (COVID-19), but so far, only one class of medications, corticosteroids, has proved useful. In recent decades, experimental therapies for cytokine storms have been tried and mostly failed to help patients with severe sepsis and other infections. We summarize this history in order to frame expectations for novel interventions in COVID-19 and to bring an evolutionary medicine perspective to the concept of cytokine storms and their treatment. Oxford University Press 2021-02-04 /pmc/articles/PMC7928963/ /pubmed/34552755 http://dx.doi.org/10.1093/emph/eoab005 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Alcock, Joe
Masters, Alix
Cytokine storms, evolution and COVID-19
title Cytokine storms, evolution and COVID-19
title_full Cytokine storms, evolution and COVID-19
title_fullStr Cytokine storms, evolution and COVID-19
title_full_unstemmed Cytokine storms, evolution and COVID-19
title_short Cytokine storms, evolution and COVID-19
title_sort cytokine storms, evolution and covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928963/
https://www.ncbi.nlm.nih.gov/pubmed/34552755
http://dx.doi.org/10.1093/emph/eoab005
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