Pitfalls when comparing COVID-19-related outcomes across studies—lessons learnt from the ERACODA collaboration

Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also me...

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Autores principales: Noordzij, Marlies, Vart, Priya, Duivenvoorden, Raphaël, Franssen, Casper F M, Hemmelder, Marc H, Jager, Kitty J, Hilbrands, Luuk B, Gansevoort, Ron T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
CKJ Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929019/
https://www.ncbi.nlm.nih.gov/pubmed/33796283
http://dx.doi.org/10.1093/ckj/sfab027
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author Noordzij, Marlies
Vart, Priya
Duivenvoorden, Raphaël
Franssen, Casper F M
Hemmelder, Marc H
Jager, Kitty J
Hilbrands, Luuk B
Gansevoort, Ron T
author_facet Noordzij, Marlies
Vart, Priya
Duivenvoorden, Raphaël
Franssen, Casper F M
Hemmelder, Marc H
Jager, Kitty J
Hilbrands, Luuk B
Gansevoort, Ron T
author_sort Noordzij, Marlies
collection PubMed
description Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also methodological aspects must be considered. In this review, we reflect on the methodological factors that contribute to the observed variation in COVID-19-related outcomes and their risk factors that are identified in the various studies. We focus on issues that arose during the design and analysis phase of the European Renal Association COVID-19 Database (ERACODA), and use examples from recently published reports on COVID-19 to illustrate these issues.
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spelling pubmed-79290192021-03-04 Pitfalls when comparing COVID-19-related outcomes across studies—lessons learnt from the ERACODA collaboration Noordzij, Marlies Vart, Priya Duivenvoorden, Raphaël Franssen, Casper F M Hemmelder, Marc H Jager, Kitty J Hilbrands, Luuk B Gansevoort, Ron T Clin Kidney J CKJ Reviews Reported outcomes, such as incidence rates of mortality and intensive care unit admission, vary widely across epidemiological coronavirus disease 2019 (COVID-19) studies, including in the nephrology field. This variation can in part be explained by differences in patient characteristics, but also methodological aspects must be considered. In this review, we reflect on the methodological factors that contribute to the observed variation in COVID-19-related outcomes and their risk factors that are identified in the various studies. We focus on issues that arose during the design and analysis phase of the European Renal Association COVID-19 Database (ERACODA), and use examples from recently published reports on COVID-19 to illustrate these issues. Oxford University Press 2021-02-02 /pmc/articles/PMC7929019/ /pubmed/33796283 http://dx.doi.org/10.1093/ckj/sfab027 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle CKJ Reviews
Noordzij, Marlies
Vart, Priya
Duivenvoorden, Raphaël
Franssen, Casper F M
Hemmelder, Marc H
Jager, Kitty J
Hilbrands, Luuk B
Gansevoort, Ron T
Pitfalls when comparing COVID-19-related outcomes across studies—lessons learnt from the ERACODA collaboration
title Pitfalls when comparing COVID-19-related outcomes across studies—lessons learnt from the ERACODA collaboration
title_full Pitfalls when comparing COVID-19-related outcomes across studies—lessons learnt from the ERACODA collaboration
title_fullStr Pitfalls when comparing COVID-19-related outcomes across studies—lessons learnt from the ERACODA collaboration
title_full_unstemmed Pitfalls when comparing COVID-19-related outcomes across studies—lessons learnt from the ERACODA collaboration
title_short Pitfalls when comparing COVID-19-related outcomes across studies—lessons learnt from the ERACODA collaboration
title_sort pitfalls when comparing covid-19-related outcomes across studies—lessons learnt from the eracoda collaboration
topic CKJ Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929019/
https://www.ncbi.nlm.nih.gov/pubmed/33796283
http://dx.doi.org/10.1093/ckj/sfab027
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