Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study

A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 10(10) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/m...

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Detalles Bibliográficos
Autores principales: Hensley, Matthew K, Bain, William G, Jacobs, Jana, Nambulli, Sham, Parikh, Urvi, Cillo, Anthony, Staines, Brittany, Heaps, Amy, Sobolewski, Michele D, Rennick, Linda J, Macatangay, Bernard J C, Klamar-Blain, Cynthia, Kitsios, Georgios D, Methé, Barbara, Somasundaram, Ashwin, Bruno, Tullia C, Cardello, Carly, Shan, Feng, Workman, Creg, Ray, Prabir, Ray, Anuradha, Lee, Janet, Sethi, Rahil, Schwarzmann, William E, Ladinsky, Mark S, Bjorkman, Pamela J, Vignali, Dario A, Duprex, W Paul, Agha, Mounzer E, Mellors, John W, McCormick, Kevin D, Morris, Alison, Haidar, Ghady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Online Only Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929077/
https://www.ncbi.nlm.nih.gov/pubmed/33507235
http://dx.doi.org/10.1093/cid/ciab072
Descripción
Sumario:A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 10(10) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.

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