Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study

A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 10(10) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/m...

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Autores principales: Hensley, Matthew K, Bain, William G, Jacobs, Jana, Nambulli, Sham, Parikh, Urvi, Cillo, Anthony, Staines, Brittany, Heaps, Amy, Sobolewski, Michele D, Rennick, Linda J, Macatangay, Bernard J C, Klamar-Blain, Cynthia, Kitsios, Georgios D, Methé, Barbara, Somasundaram, Ashwin, Bruno, Tullia C, Cardello, Carly, Shan, Feng, Workman, Creg, Ray, Prabir, Ray, Anuradha, Lee, Janet, Sethi, Rahil, Schwarzmann, William E, Ladinsky, Mark S, Bjorkman, Pamela J, Vignali, Dario A, Duprex, W Paul, Agha, Mounzer E, Mellors, John W, McCormick, Kevin D, Morris, Alison, Haidar, Ghady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Online Only Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929077/
https://www.ncbi.nlm.nih.gov/pubmed/33507235
http://dx.doi.org/10.1093/cid/ciab072
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author Hensley, Matthew K
Bain, William G
Jacobs, Jana
Nambulli, Sham
Parikh, Urvi
Cillo, Anthony
Staines, Brittany
Heaps, Amy
Sobolewski, Michele D
Rennick, Linda J
Macatangay, Bernard J C
Klamar-Blain, Cynthia
Kitsios, Georgios D
Methé, Barbara
Somasundaram, Ashwin
Bruno, Tullia C
Cardello, Carly
Shan, Feng
Workman, Creg
Ray, Prabir
Ray, Anuradha
Lee, Janet
Sethi, Rahil
Schwarzmann, William E
Ladinsky, Mark S
Bjorkman, Pamela J
Vignali, Dario A
Duprex, W Paul
Agha, Mounzer E
Mellors, John W
McCormick, Kevin D
Morris, Alison
Haidar, Ghady
author_facet Hensley, Matthew K
Bain, William G
Jacobs, Jana
Nambulli, Sham
Parikh, Urvi
Cillo, Anthony
Staines, Brittany
Heaps, Amy
Sobolewski, Michele D
Rennick, Linda J
Macatangay, Bernard J C
Klamar-Blain, Cynthia
Kitsios, Georgios D
Methé, Barbara
Somasundaram, Ashwin
Bruno, Tullia C
Cardello, Carly
Shan, Feng
Workman, Creg
Ray, Prabir
Ray, Anuradha
Lee, Janet
Sethi, Rahil
Schwarzmann, William E
Ladinsky, Mark S
Bjorkman, Pamela J
Vignali, Dario A
Duprex, W Paul
Agha, Mounzer E
Mellors, John W
McCormick, Kevin D
Morris, Alison
Haidar, Ghady
author_sort Hensley, Matthew K
collection PubMed
description A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 10(10) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.
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spelling pubmed-79290772021-03-04 Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study Hensley, Matthew K Bain, William G Jacobs, Jana Nambulli, Sham Parikh, Urvi Cillo, Anthony Staines, Brittany Heaps, Amy Sobolewski, Michele D Rennick, Linda J Macatangay, Bernard J C Klamar-Blain, Cynthia Kitsios, Georgios D Methé, Barbara Somasundaram, Ashwin Bruno, Tullia C Cardello, Carly Shan, Feng Workman, Creg Ray, Prabir Ray, Anuradha Lee, Janet Sethi, Rahil Schwarzmann, William E Ladinsky, Mark S Bjorkman, Pamela J Vignali, Dario A Duprex, W Paul Agha, Mounzer E Mellors, John W McCormick, Kevin D Morris, Alison Haidar, Ghady Clin Infect Dis Online Only Articles A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 10(10) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible. Oxford University Press 2021-01-28 /pmc/articles/PMC7929077/ /pubmed/33507235 http://dx.doi.org/10.1093/cid/ciab072 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
spellingShingle Online Only Articles
Hensley, Matthew K
Bain, William G
Jacobs, Jana
Nambulli, Sham
Parikh, Urvi
Cillo, Anthony
Staines, Brittany
Heaps, Amy
Sobolewski, Michele D
Rennick, Linda J
Macatangay, Bernard J C
Klamar-Blain, Cynthia
Kitsios, Georgios D
Methé, Barbara
Somasundaram, Ashwin
Bruno, Tullia C
Cardello, Carly
Shan, Feng
Workman, Creg
Ray, Prabir
Ray, Anuradha
Lee, Janet
Sethi, Rahil
Schwarzmann, William E
Ladinsky, Mark S
Bjorkman, Pamela J
Vignali, Dario A
Duprex, W Paul
Agha, Mounzer E
Mellors, John W
McCormick, Kevin D
Morris, Alison
Haidar, Ghady
Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study
title Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study
title_full Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study
title_fullStr Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study
title_full_unstemmed Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study
title_short Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study
title_sort intractable coronavirus disease 2019 (covid-19) and prolonged severe acute respiratory syndrome coronavirus 2 (sars-cov-2) replication in a chimeric antigen receptor-modified t-cell therapy recipient: a case study
topic Online Only Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929077/
https://www.ncbi.nlm.nih.gov/pubmed/33507235
http://dx.doi.org/10.1093/cid/ciab072
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