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The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1

Endoplasmic reticulum–associated degradation (ERAD) is a process directing misfolded proteins from the ER lumen and membrane to the degradation machinery in the cytosol. A key step in ERAD is the translocation of ER proteins to the cytosol. Derlins are essential for protein translocation in ERAD, bu...

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Detalles Bibliográficos
Autores principales:	Rao, Bing, Li, Shaobai, Yao, Deqiang, Wang, Qian, Xia, Ying, Jia, Yi, Shen, Yafeng, Cao, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929502/ https://www.ncbi.nlm.nih.gov/pubmed/33658201 http://dx.doi.org/10.1126/sciadv.abe8591

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