Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers

Basal-like breast cancer (BLBC) shows brain metastatic (BM) capability and overexpresses EGFR and death-receptors 4/5 (DR4/5); however, the anatomical location of BM prohibits efficient drug-delivery to these targetable markers. In this study, we developed BLBC-BM mouse models featuring different pa...

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Detalles Bibliográficos
Autores principales: Kitamura, Yohei, Kanaya, Nobuhiko, Moleirinho, Susana, Du, Wanlu, Reinshagen, Clemens, Attia, Nada, Bronisz, Agnieszka, Revai Lechtich, Esther, Sasaki, Hikaru, Mora, Joana Liliana, Brastianos, Priscilla Kaliopi, Falcone, Jefferey L., Hofer, Aldebaran M., Franco, Arnaldo, Shah, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929513/
https://www.ncbi.nlm.nih.gov/pubmed/33658202
http://dx.doi.org/10.1126/sciadv.abe8671

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