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α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

The Parkinson’s disease protein α-synuclein (αSyn) promotes membrane fusion and fission by interacting with various negatively charged phospholipids. Despite postulated roles in endocytosis and exocytosis, plasma membrane (PM) interactions of αSyn are poorly understood. Here, we show that phosphatid...

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Detalles Bibliográficos
Autores principales: Jacob, Reeba Susan, Eichmann, Cédric, Dema, Alessandro, Mercadante, Davide, Selenko, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929559/
https://www.ncbi.nlm.nih.gov/pubmed/33587036
http://dx.doi.org/10.7554/eLife.61951

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