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Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling

Historical literature and pharmacological studies demonstrate that Astragalus polysaccharide (APS) has anti-inflammatory and antioxidative effects. Studies into the longevity effects of APS are limited, and the molecular mechanism of lifespan extension by APS is not elucidated yet. Here, the longevi...

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Autores principales: Yang, Fujia, Xiu, Minghui, Yang, Shipei, Li, Xu, Tuo, Wenjuan, Su, Yun, He, Jianzheng, Liu, Yongqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929661/
https://www.ncbi.nlm.nih.gov/pubmed/33680062
http://dx.doi.org/10.1155/2021/6686748
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author Yang, Fujia
Xiu, Minghui
Yang, Shipei
Li, Xu
Tuo, Wenjuan
Su, Yun
He, Jianzheng
Liu, Yongqi
author_facet Yang, Fujia
Xiu, Minghui
Yang, Shipei
Li, Xu
Tuo, Wenjuan
Su, Yun
He, Jianzheng
Liu, Yongqi
author_sort Yang, Fujia
collection PubMed
description Historical literature and pharmacological studies demonstrate that Astragalus polysaccharide (APS) has anti-inflammatory and antioxidative effects. Studies into the longevity effects of APS are limited, and the molecular mechanism of lifespan extension by APS is not elucidated yet. Here, the longevity effect of APS was investigated in Drosophila melanogaster by feeding dose-dependent APS. APS significantly extended the lifespan and improved the reproduction. Meanwhile, APS increased locomotion, TAG level, and starvation resistance and reduced the mortality rate induced by hydrogen peroxide. The activities of superoxide dismutase (SOD) and catalase (CAT) were increased in flies treated with APS diet. Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E − BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. Together, these results indicate that APS can prolong the lifespan by regulating antioxidant ability and insulin/IGF-1 signaling and also enhance the reproduction ability in Drosophila. APS may be explored as a novel agent for slowing the aging process and improving reproduction.
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spelling pubmed-79296612021-03-04 Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling Yang, Fujia Xiu, Minghui Yang, Shipei Li, Xu Tuo, Wenjuan Su, Yun He, Jianzheng Liu, Yongqi Evid Based Complement Alternat Med Research Article Historical literature and pharmacological studies demonstrate that Astragalus polysaccharide (APS) has anti-inflammatory and antioxidative effects. Studies into the longevity effects of APS are limited, and the molecular mechanism of lifespan extension by APS is not elucidated yet. Here, the longevity effect of APS was investigated in Drosophila melanogaster by feeding dose-dependent APS. APS significantly extended the lifespan and improved the reproduction. Meanwhile, APS increased locomotion, TAG level, and starvation resistance and reduced the mortality rate induced by hydrogen peroxide. The activities of superoxide dismutase (SOD) and catalase (CAT) were increased in flies treated with APS diet. Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E − BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. Together, these results indicate that APS can prolong the lifespan by regulating antioxidant ability and insulin/IGF-1 signaling and also enhance the reproduction ability in Drosophila. APS may be explored as a novel agent for slowing the aging process and improving reproduction. Hindawi 2021-02-24 /pmc/articles/PMC7929661/ /pubmed/33680062 http://dx.doi.org/10.1155/2021/6686748 Text en Copyright © 2021 Fujia Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Fujia
Xiu, Minghui
Yang, Shipei
Li, Xu
Tuo, Wenjuan
Su, Yun
He, Jianzheng
Liu, Yongqi
Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling
title Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling
title_full Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling
title_fullStr Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling
title_full_unstemmed Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling
title_short Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling
title_sort extension of drosophila lifespan by astragalus polysaccharide through a mechanism dependent on antioxidant and insulin/igf-1 signaling
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929661/
https://www.ncbi.nlm.nih.gov/pubmed/33680062
http://dx.doi.org/10.1155/2021/6686748
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