Cargando…

Protective/reparative cytokines are suppressed at high injury severity in human trauma

BACKGROUND: Trauma elicits a complex inflammatory response that, among multiple presenting factors, is greatly impacted by the magnitude of injury severity. Herein, we compared the changes in circulating levels of mediators with known proinflammatory roles to those with known protective/reparative a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Jinman, McKinley, Todd, Billiar, Isabel, Zenati, Mazen S, Gaski, Greg, Vodovotz, Yoram, Gruen, Danielle S, Billiar, Timothy R, Namas, Rami A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929818/ https://www.ncbi.nlm.nih.gov/pubmed/33748428 http://dx.doi.org/10.1136/tsaco-2020-000619

Ejemplares similares

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries
por: Almahmoud, Khalid, et al.
Publicado: (2019)

Insights into the association between coagulopathy and inflammation: abnormal clot mechanics are a warning of immunologic dysregulation following major injury
por: Savage, Stephanie A., et al.
Publicado: (2020)

Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill
por: Bonaroti, Jillian, et al.
Publicado: (2022)

Time for trauma immunology
por: Billiar, Timothy R., et al.
Publicado: (2017)

Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients
por: Liu, Dongmei, et al.
Publicado: (2020)

The independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whole blood leukocyte transcriptomes across three etiologies of critical illness
por: Chen, Tianmeng, et al.
Publicado: (2022)

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice
por: Namas, Rami A., et al.
Publicado: (2013)

The Acute Inflammatory Response in Trauma / Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects
por: Namas, R, et al.
Publicado: (2009)

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model
por: Xu, Jing, et al.
Publicado: (2017)

MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes
por: Schimunek, Lukas, et al.
Publicado: (2019)

Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma
por: Zaaqoq, Akram M., et al.
Publicado: (2019)

LONGITUDINAL ANALYSIS OF TRANSCRIPTOMIC SUBTYPES IN TRAUMA PATIENTS
por: Chen, Tianmeng, et al.
Publicado: (2022)

Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes
por: Schimunek, Lukas, et al.
Publicado: (2021)

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients
por: Abdul-Malak, Othman, et al.
Publicado: (2016)

A Dynamic View of Trauma/Hemorrhage-Induced Inflammation in Mice: Principal Drivers and Networks
por: Mi, Qi, et al.
Publicado: (2011)

Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies
por: Ziraldo, Cordelia, et al.
Publicado: (2013)

“Thinking” vs. “Talking”: Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress
por: Vodovotz, Yoram, et al.
Publicado: (2017)

A road map from single-cell transcriptome to patient classification for the immune response to trauma
por: Chen, Tianmeng, et al.
Publicado: (2021)

ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing
por: Guo, Xinfeng, et al.
Publicado: (2023)

Inferring Tissue-Specific, TLR4-Dependent Type 17 Immune Interactions in Experimental Trauma/Hemorrhagic Shock and Resuscitation Using Computational Modeling
por: Shah, Ashti M., et al.
Publicado: (2022)

Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis
por: Bagci, Elife Z., et al.
Publicado: (2008)

ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway
por: Guo, Xinfeng, et al.
Publicado: (2021)

A putative “chemokine switch” that regulates systemic acute inflammation in humans
por: Azhar, Nabil, et al.
Publicado: (2021)

Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks
por: Zamora, Ruben, et al.
Publicado: (2021)

An Adequately Robust Early TNF-α Response Is a Hallmark of Survival Following Trauma/Hemorrhage
por: Namas, Rajaie, et al.
Publicado: (2009)

Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice
por: Zettel, Kent, et al.
Publicado: (2017)

Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses
por: Wu, Junru, et al.
Publicado: (2021)

Lipidomic Signatures Align with Inflammatory Patterns and Outcomes in Critical Illness
por: Wu, Junru, et al.
Publicado: (2021)

A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes
por: El-Dehaibi, Fayten, et al.
Publicado: (2023)

Divergence of military and civilian trauma research priorities
por: Baer, David, et al.
Publicado: (2021)

Lipidomic signatures align with inflammatory patterns and outcomes in critical illness
por: Wu, Junru, et al.
Publicado: (2022)

Editorial: Translational Insights Into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma
por: Radermacher, Peter, et al.
Publicado: (2020)

Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients
por: Abdelhamid, Sultan S., et al.
Publicado: (2022)

Polytraumatized patient lower extremity nonunion development: Raw data
por: Sardesai, Neil R., et al.
Publicado: (2021)

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen
por: Zamora, Ruben, et al.
Publicado: (2019)

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice
por: Zamora, Ruben, et al.
Publicado: (2018)

Innate-Like Lymphocytes Are Immediate Participants in the Hyper-Acute Immune Response to Trauma and Hemorrhagic Shock
por: Manson, Joanna, et al.
Publicado: (2019)

Tunnel LEP: Réparations
Publicado: (1990)

Repare su carburador
por: Whittington, Herschel
Publicado: (1995)

Love, Hate and Reparation
por: Toynbee, S. A.
Publicado: (1954)

Cannot write session to /tmp/vufind_sessions/sess_a084ckibmpcem7q1k9adjm6uj4