The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A

The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens. SARS-CoV-2 RBD binds the blood group A expressed on respiratory epithelial cells, directly linking blood group A and SARS-CoV-2.

Detalles Bibliográficos
Autores principales: Wu, Shang-Chuen, Arthur, Connie M., Wang, Jianmei, Verkerke, Hans, Josephson, Cassandra D., Kalman, Daniel, Roback, John D., Cummings, Richard D., Stowell, Sean R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2021
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929867/
https://www.ncbi.nlm.nih.gov/pubmed/33656534
http://dx.doi.org/10.1182/bloodadvances.2020003259
Descripción
Sumario:The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens. SARS-CoV-2 RBD binds the blood group A expressed on respiratory epithelial cells, directly linking blood group A and SARS-CoV-2.

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