GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematological malignancy with high incidence and recurrence rates. Gene expression profiling has revealed that transcriptional overexpression of glioma‐associated oncogene 1 (GLI1), a vital gene in the Hedgehog (Hh) signaling pathway, occurs in poor-prognosis AML, a...

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Detalles Bibliográficos
Autores principales: Zhou, Cheng, Du, Juan, Zhao, Liang, Liu, Wei, Zhao, Tianming, Liang, Hui, Fang, Peng, Zhang, Kaixuan, Zeng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930050/
https://www.ncbi.nlm.nih.gov/pubmed/33658491
http://dx.doi.org/10.1038/s41419-021-03504-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930050/
https://www.ncbi.nlm.nih.gov/pubmed/33658491
http://dx.doi.org/10.1038/s41419-021-03504-2

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