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GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematological malignancy with high incidence and recurrence rates. Gene expression profiling has revealed that transcriptional overexpression of glioma‐associated oncogene 1 (GLI1), a vital gene in the Hedgehog (Hh) signaling pathway, occurs in poor-prognosis AML, a...

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Detalles Bibliográficos
Autores principales:	Zhou, Cheng, Du, Juan, Zhao, Liang, Liu, Wei, Zhao, Tianming, Liang, Hui, Fang, Peng, Zhang, Kaixuan, Zeng, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930050/ https://www.ncbi.nlm.nih.gov/pubmed/33658491 http://dx.doi.org/10.1038/s41419-021-03504-2

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